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Literature summary extracted from

  • Klaus, C.; Jeon, M.K.; Kaemmerer, E.; Gassler, N.
    Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind (2013), World J. Gastroenterol., 19, 7369-7373.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 Triacsin C i.e. 1-hydroxy-3-(E,E,E-2',4',7'-undecatrienylidine)triazene, potent competitive inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA Homo sapiens
-
 AMP + diphosphate + a long-chain fatty acyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 enterocyte highest expression level in enterocytes at the villus tip Homo sapiens
-
6.2.1.3 small intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA
-
 Homo sapiens AMP + diphosphate + a long-chain fatty acyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL5
-
 Homo sapiens
6.2.1.3 acyl-CoA synthetase 5
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
6.2.1.3 Homo sapiens adenocarcinomas with an invasive phenotype and enhanced proliferation show decreased levels of isoform ACSL5 down

General Information

EC Number General Information Comment Organism
6.2.1.3 metabolism acyl-CoA synthetase 5 plays a key role in fatty acid metabolism. Isoform ACSL5 plays a role in channelling fatty acids towards palmitoylation and other lipid functions with high relevance for cellular behaviour Homo sapiens