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Literature summary extracted from

  • D'Angelo, I.; Raffaelli, N.; Dabusti, V.; Lorenzi, T.; Magni, G.; Rizzi, M.
    Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD(+) biosynthesis (2000), Structure, 8, 993-1004.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.1 medicine given its vital role in cell life, the enzyme represents a possible target for the development of new antibacterial agents Methanocaldococcus jannaschii

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.1 crystals of the enzyme in complex with ATP are grown using the hanging-drop vapor-diffusion method. The structure in complex with ATP has been solved by X-ray crystallography at 2.0 A resolution, using a combination of single isomorphous replacement and density modification techniques. The structure reveals a hexamer with 32 point group symmetry composed of alpha/beta topology subunits Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Methanocaldococcus jannaschii the enzyme plays a key role in NAD+ biosynthesis diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide Methanocaldococcus jannaschii DSM 2661 the enzyme plays a key role in NAD+ biosynthesis diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Methanocaldococcus jannaschii Q57961
-
-
2.7.7.1 Methanocaldococcus jannaschii DSM 2661 Q57961
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide the enzyme plays a key role in NAD+ biosynthesis Methanocaldococcus jannaschii diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide the enzyme plays a key role in NAD+ biosynthesis Methanocaldococcus jannaschii DSM 2661 diphosphate + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.1 hexamer
-
 Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 NMN AT
-
 Methanocaldococcus jannaschii

General Information

EC Number General Information Comment Organism
2.7.7.1 physiological function the enzyme plays a key role in NAD+ biosynthesis Methanocaldococcus jannaschii