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Literature summary extracted from

  • Kapoor, A.; Shandilya, M.; Kundu, S.
    Structural insight of dopamine beta-hydroxylase, a drug target for complex traits, and functional significance of exonic single nucleotide polymorphisms (2011), PLoS ONE, 6, e26509.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.17.1 A318S the mutation does not influence enzyme activity Homo sapiens
1.14.17.1 G482R the mutation has subsequent effect on the activity of the enzyme as it is present close to the active site Homo sapiens
1.14.17.1 L317P the mutation does not influence enzyme activity Homo sapiens
1.14.17.1 R549C the mutation causes abnormal oligomerization through non-native disulfide bond formation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 nepicastat
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.1 copper contains copper Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2 Homo sapiens
-
 noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Homo sapiens P09172
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2
-
 Homo sapiens noradrenaline + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
-
 Homo sapiens
1.14.17.1 dopamine beta-hydroxylase
-
 Homo sapiens