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Literature summary extracted from

  • Zhang, C.; Cahoon, R.E.; Hunter, S.C.; Chen, M.; Han, J.; Cahoon, E.B.
    Genetic and biochemical basis for alternative routes of tocotrienol biosynthesis for enhanced vitamin E antioxidant production (2013), Plant J., 73, 628-639.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.116 synthesis combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.115 geranylgeranyl diphosphate + homogentisate Arabidopsis thaliana
-
 diphosphate + 2-methyl-6-geranylgeranylbenzoquinol + CO2
-
 ?
2.5.1.115 additional information Arabidopsis thaliana recombinant Arabidopsis thaliana HPT preferentially catalyzes in vitro production of the tocotrienol precursor geranylgeranyl benzoquinol only when presented with high molar ratios of geranylgeranyl diphosphate:phytyl diphosphate ?
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate Arabidopsis thaliana
-
 diphosphate + 2-methyl-6-phytylbenzoquinol + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.115 Arabidopsis thaliana Q8VWJ1
-
-
2.5.1.116 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.115 geranylgeranyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + 2-methyl-6-geranylgeranylbenzoquinol + CO2
-
 ?
2.5.1.115 additional information recombinant Arabidopsis thaliana HPT preferentially catalyzes in vitro production of the tocotrienol precursor geranylgeranyl benzoquinol only when presented with high molar ratios of geranylgeranyl diphosphate:phytyl diphosphate Arabidopsis thaliana ?
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + 2-methyl-6-phytylbenzoquinol + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.115 HPT1
-
 Arabidopsis thaliana
2.5.1.115 VTE2-1
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.5.1.115 physiological function an Arabidopsis thalina that accumulates tocotrienols and homogentisate by co-expression of Arabidopsis thaliana hydroxyphenylpyruvate dioxygenase and Escherichia coli bi-functional chorismate mutase/prephenate dehydrogenase loses tocotrienol production when crossed into the vte2-1 HPT null mutant. Hydroxyphenylpyruvate dioxygenase/TyrA-induced tocotrienol production requires HPT and occurs upon enrichment of geranylgeranyl diphosphaterelative to phytyl diphosphate in prenyl diphosphate pools Arabidopsis thaliana
2.5.1.116 physiological function combined expression of hydroxyphenylpyruvate dioxygenase/bi-functional chorismate mutase/prephenate dehydrogenase and homogentisate geranylgeranyl transferase in Arabidopsis leaves and seeds results in large additive increases in vitamin E production, indicating that homogentisate concentrations limit homogentisate geranylgeranyl transferase-catalyzed tocotrienol synthesis Arabidopsis thaliana