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Literature summary extracted from

  • Cathcart, M.C.; Gately, K.; Cummins, R.; Kay, E.; OByrne, K.J.; Pidgeon, G.P.
    Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer (2011), Mol. Cancer, 10, 25.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.5 stable overexpression of thromboxane synthase in SKMES-1 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 ozagrel
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 A-549 cell an adenocarcinoma cell line Homo sapiens
-
5.3.99.5 non-small cell lung cancer cell adenocarcinomas and squamous cell carcinomas, enzyme expression profile, overview. Enzyme expression is higher in adenocarcinoma and female patients Homo sapiens
-
5.3.99.5 SK-MES-1 cell a squamous cell carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.5 thromboxane synthase
-
 Homo sapiens
5.3.99.5 TXS
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
5.3.99.5 malfunction enzyme inhibition induces cell death in vitro. Selective TXS inhibition significantly reduces tumour cell growth and increases apoptosis, while TXS overexpression stimulates cell proliferation and invasiveness, and is protective against apoptosis, quantification of multi-parameter apoptosis signalling, overview Homo sapiens
5.3.99.5 physiological function thromboxane synthase metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS overexpression occurs in a range of cancers, and associated with a poor prognosis, although in non-small lung cancer cells, no significant correlation with patient survival is observed Homo sapiens