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Literature summary extracted from
- Holocarboxylase synthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events (2013), J. Nutr. Biochem., 24, 1446-1452.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.4.10 | ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | Homo sapiens | - |
AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.3.4.10 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.4.10 | ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | - |
Homo sapiens | AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.3.4.10 | HCS | - |
Homo sapiens |
| 6.3.4.10 | Holocarboxylase synthetase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.4.10 | ATP | - |
Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 6.3.4.10 | metabolism | holocarboxylase synthetase catalyzes the binding of the vitamin biotin to histones H3 and H4, thereby creating rare histone biotinylation marks in the epigenome. The enzyme interacts physically with euchromatic histone-lysine N-methyltransferase | Homo sapiens |
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Release 2023.1 (January 2023)
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