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Literature summary extracted from

  • Bouvier, G.; Duclert-Savatier, N.; Desdouits, N.; Meziane-Cherif, D.; Blondel, A.; Courvalin, P.; Nilges, M.; Malliavin, T.E.
    Functional motions modulating VanA ligand binding unraveled by self-organizing maps (2014), J. Chem. Inf. Model., 54, 289-301.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecium
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP Enterococcus faecium BM4147
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.2.1 Enterococcus faecium P25051
-
-
6.1.2.1 Enterococcus faecium BM4147 P25051
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
6.1.2.1 D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium BM4147 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.2.1 D-Ala:D-Lac ligase
-
 Enterococcus faecium
6.1.2.1 VanA
-
 Enterococcus faecium

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.2.1 ATP
-
 Enterococcus faecium

General Information

EC Number General Information Comment Organism
6.1.2.1 physiological function the enzyme is a key enzyme in the emergence of high level resistance to vancomycin in Enterococcus Enterococcus faecium