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Literature summary extracted from

  • Manjunath, K.; Sekar, K.
    Molecular dynamics perspective on the protein thermal stability: a case study using SAICAR synthetase (2013), J. Chem. Inf. Model., 53, 2448-2461.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Escherichia coli
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Ehrlichia chaffeensis
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Geobacillus kaustophilus
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Pyrococcus horikoshii
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Methanocaldococcus jannaschii
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Pyrococcus horikoshii DSM 12428
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Methanocaldococcus jannaschii DSM 2661
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.6 Ehrlichia chaffeensis
-
-
-
6.3.2.6 Escherichia coli
-
-
-
6.3.2.6 Geobacillus kaustophilus
-
-
-
6.3.2.6 Methanocaldococcus jannaschii Q58987
-
-
6.3.2.6 Methanocaldococcus jannaschii DSM 2661 Q58987
-
-
6.3.2.6 Pyrococcus horikoshii O57978
-
-
6.3.2.6 Pyrococcus horikoshii DSM 12428 O57978
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Escherichia coli ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Ehrlichia chaffeensis ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Geobacillus kaustophilus ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Pyrococcus horikoshii ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Methanocaldococcus jannaschii ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Pyrococcus horikoshii DSM 12428 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Methanocaldococcus jannaschii DSM 2661 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.6 dimer
-
 Escherichia coli
6.3.2.6 dimer
-
 Ehrlichia chaffeensis
6.3.2.6 dimer
-
 Geobacillus kaustophilus
6.3.2.6 dimer
-
 Pyrococcus horikoshii
6.3.2.6 dimer
-
 Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
6.3.2.6 MjSS
-
 Methanocaldococcus jannaschii
6.3.2.6 PhSS
-
 Pyrococcus horikoshii
6.3.2.6 SAICAR synthetase
-
 Escherichia coli
6.3.2.6 SAICAR synthetase
-
 Ehrlichia chaffeensis
6.3.2.6 SAICAR synthetase
-
 Geobacillus kaustophilus
6.3.2.6 SAICAR synthetase
-
 Pyrococcus horikoshii
6.3.2.6 SAICAR synthetase
-
 Methanocaldococcus jannaschii

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.3.2.6 additional information
-
 27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Escherichia coli
6.3.2.6 additional information
-
 27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Ehrlichia chaffeensis
6.3.2.6 additional information
-
 27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Geobacillus kaustophilus
6.3.2.6 additional information
-
 delineation of the mesophilic (Escherichia coli, Ehrlichia chaffeensis), thermophilic (Geobacillus kaustophilus), and hyperthermophilic (Methanocaldococcus jannaschii, Pyrococcus horikoshii) proteins on the basis of their thermal stability by studying their dynamic aspects at 27°C and 60°C using molecular dynamics Pyrococcus horikoshii
6.3.2.6 additional information
-
 delineation of the mesophilic (Escherichia coli, Ehrlichia chaffeensis), thermophilic (Geobacillus kaustophilus), and hyperthermophilic (Methanocaldococcus jannaschii, Pyrococcus horikoshii) proteins on the basis of their thermal stability by studying their dynamic aspects at 27°C and 60°C using molecular dynamics Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.6 ATP
-
 Escherichia coli
6.3.2.6 ATP
-
 Ehrlichia chaffeensis
6.3.2.6 ATP
-
 Geobacillus kaustophilus

General Information

EC Number General Information Comment Organism
6.3.2.6 additional information structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Escherichia coli
6.3.2.6 additional information structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Ehrlichia chaffeensis
6.3.2.6 additional information structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview Geobacillus kaustophilus