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Literature summary extracted from

  • Aarhus, R.; Graeff, R.M.; Dickey, D.M.; Walseth, T.F.; Lee, H.C.
    ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP+ (1995), J. Biol. Chem., 270, 30327-30333.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.99.20 5
-
 nicotinate pH 5, 22°C Homo sapiens
2.4.99.20 5
-
 nicotinate pH 5, 22°C Aplysia californica

Organism

EC Number Organism UniProt Comment Textmining
2.4.99.20 Aplysia californica P29241 bifunctional enzyme that can synthesize cADPR from NAD1 as well as hydrolyze cADPR to ADP-ribose
-
2.4.99.20 Homo sapiens P28907 bifunctional enzyme that can synthesize cADPR from NAD1 as well as hydrolyze cADPR to ADP-ribose
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Homo sapiens nicotinate-adenine dinucleotide phosphate
-
 ?
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
 Aplysia californica nicotinate-adenine dinucleotide phosphate
-
 ?
2.4.99.20 additional information in the absence of nicotinic acid or at neutral pH, isoform CD38 converts NADP+ to ADP-ribose 2'-phosphate, which is the hydrolysis product of cyclic ADPribose 2'-phosphate, reaction of EC 3.2.2.6 Aplysia californica ?
-
 ?
2.4.99.20 additional information the switch of the catalysis to the exchange reaction requires acidic pH and nicotinic acid. In the absence of nicotinic acid or at neutral pH, the cyclase converts NADP+ to cyclic ADP-ribose 2'-phosphate Homo sapiens ?
-
 ?
2.4.99.20 NADP+
-
 Homo sapiens 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?
2.4.99.20 NADP+
-
 Aplysia californica 2'-phospho-cyclic ADP-ribose + nicotinamide
-
 ?