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Literature summary extracted from

  • Omi, R.; Mizuguchi, H.; Goto, M.; Miyahara, I.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
    Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling (2002), J. Biochem., 132, 759-765.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.3.1.B2 crystals are obtained by the hanging-drop vapor diffusion method at 20°C. Within two weeks, the crystals grow to full size (0.3 x 0.3 x 0.2 mm) in the space group P4(3)2(1)2 with unit cell parameters a = b = 82.2, c = 156.2 A. X-ray crystallographic study of the native enzyme at 2.3 A resolution Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate Thermus thermophilus the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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 ?
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate Thermus thermophilus HB8 / ATCC 27634 / DSM 579 the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.B2 Thermus thermophilus
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4.3.1.B2 Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
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 Thermus thermophilus L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate
-
 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
4.3.1.B2 L-glutamine + N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate the enzyme catalyzes a step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus HB8 / ATCC 27634 / DSM 579 L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?

General Information

EC Number General Information Comment Organism
4.3.1.B2 metabolism the enzyme catalyzes the fifth step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis Thermus thermophilus