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Literature summary extracted from

  • Sorci, L.; Blaby,I.K.; Rodionova, I.A.; De Ingeniis, J.; Tkachenko, S.; de Crécy-Lagard, V.; Osterman, A.L.
    uinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci (2013), J. Bacteriol., 195, 726-732.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.18 K891-0166
-
 Streptococcus pyogenes

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.01
-
 pyridine-2,3-dicarboxylate 37°C, pH 7.5 Streptococcus pyogenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.19 31700
-
 calculated from amino acid sequence Streptococcus pyogenes
2.7.7.18 24350
-
 calculated from amino acid sequence Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate Streptococcus pyogenes
-
 nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate Streptococcus pyogenes ATCC BAA-946
-
 nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?
2.7.7.18 ATP + beta-nicotinate D-ribonucleotide Streptococcus pyogenes
-
 diphosphate + deamido-NAD+
-
 ?
2.7.7.18 ATP + beta-nicotinate D-ribonucleotide Streptococcus pyogenes ATCC BAA-946
-
 diphosphate + deamido-NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Streptococcus pyogenes Q5XBL7 serotype M6
-
2.4.2.19 Streptococcus pyogenes ATCC BAA-946 Q5XBL7 serotype M6
-
2.7.7.18 Streptococcus pyogenes Q5XDT7 serotype M6
-
2.7.7.18 Streptococcus pyogenes ATCC BAA-946 Q5XDT7 serotype M6
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Streptococcus pyogenes nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Streptococcus pyogenes ATCC BAA-946 nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?
2.7.7.18 ATP + beta-nicotinate D-ribonucleotide
-
 Streptococcus pyogenes diphosphate + deamido-NAD+
-
 ?
2.7.7.18 ATP + beta-nicotinate D-ribonucleotide
-
 Streptococcus pyogenes ATCC BAA-946 diphosphate + deamido-NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.19 M6_Spy1061 locus name Streptococcus pyogenes
2.4.2.19 sp.NadC
-
 Streptococcus pyogenes
2.7.7.18 M6_Spy0291 locus name Streptococcus pyogenes
2.7.7.18 sp.NadD
-
 Streptococcus pyogenes

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.19 6
-
 pyridine-2,3-dicarboxylate 37°C, pH 7.5 Streptococcus pyogenes

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.18 0.0079
-
 K891-0166 pH 7.5, 37°C Streptococcus pyogenes

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.18 0.015
-
 pH 7.5, 37°C Streptococcus pyogenes K891-0166