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Literature summary extracted from

  • Tahlan, K.; Jensen, S.
    Origins of the beta-lactam rings in natural products (2013), J. Antibiot., 66, 401-410.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.3.6 ATP + (2S,5S)-5-carboxymethylproline Pectobacterium carotovorum
-
 AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate
-
 ?
6.3.3.6 ATP + (2S,5S)-5-carboxymethylproline Streptomyces cattleya
-
 AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.6 Pectobacterium carotovorum Q9XB61
-
-
6.3.3.6 Streptomyces cattleya Q83XP1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.6 ATP + (2S,5S)-5-carboxymethylproline
-
 Pectobacterium carotovorum AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate
-
 ?
6.3.3.6 ATP + (2S,5S)-5-carboxymethylproline
-
 Streptomyces cattleya AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.3.6 carbapenam synthetase
-
 Pectobacterium carotovorum
6.3.3.6 carbapenam synthetase
-
 Streptomyces cattleya
6.3.3.6 CPS
-
 Pectobacterium carotovorum
6.3.3.6 CPS
-
 Streptomyces cattleya

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.3.6 ATP
-
 Pectobacterium carotovorum
6.3.3.6 ATP
-
 Streptomyces cattleya