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Literature summary extracted from
- Cortisol production in sheep is influenced by the functional expression of two cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) isoforms (2013), J. Anim. Sci., 91, 1193-1206.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.19 | DNA and amino acid sequence determination and analysis, CYP17 genotyping, realtime PCR expression analysis | Ovis aries |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.19 | 0.0016 | - |
progesterone | isozyme 1, pH 7.4, temperature not specified in the publication | Ovis aries |  |
| 1.14.14.19 | 0.0017 | - |
pregnenolone | isozyme 1, pH 7.4, temperature not specified in the publication | Ovis aries | |
| 1.14.14.19 | 0.0018 | - |
progesterone | isozyme 2, pH 7.4, temperature not specified in the publication | Ovis aries | |
| 1.14.14.19 | 0.0019 | - |
pregnenolone | isozyme 2, pH 7.4, temperature not specified in the publication | Ovis aries | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.19 | microsome | - |
Ovis aries | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | additional information | Ovis aries | the bifunctional enzyme catalyzes two types of reactions, namely, a 17alpha-hydroxylation reaction and a 17,20-lyase reaction | ? | - |
? | |
| 1.14.14.19 | pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | Ovis aries | - |
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Ovis aries | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | Ovis aries | Q29497 | GenBank accession numbers L40335 and AF251388 encodíng isozymes 1 and 2; two isozymes of cytochrome P450 17alpha-hydroxylase/17,20-lyase, that differ in two nucleotides, resulting in variants Ser210Gly and Tyr464Asn | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.19 | adrenal cortex | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.19 | additional information | the bifunctional enzyme catalyzes two types of reactions, namely, a 17alpha-hydroxylation reaction and a 17,20-lyase reaction | Ovis aries | ? | - |
? | |
| 1.14.14.19 | pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Ovis aries | 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| 1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Ovis aries | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.19 | CYP17 | - |
Ovis aries |
| 1.14.14.19 | cytochrome P450 17alpha-hydroxylase/17,20-lyase | - |
Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.19 | 7.4 | - |
assay at | Ovis aries |
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Release 2023.1 (January 2023)
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