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Literature summary extracted from

  • Bae, Y.A.; Cai, G.B.; Kim, S.H.; Sohn, W.M.; Kong, Y.
    Expression pattern and substrate specificity of Clonorchis sinensis tyrosinases (2013), Int. J. Parasitol., 43, 891-900.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.3.1 expressed in Escherichia coli BL21(DE3) cells Clonorchis sinensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.1 diethyldithiocarbamic acid
-
 Clonorchis sinensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.3.1 1.6 2 L-Dopa at pH 7.0 and 37°C Clonorchis sinensis
1.10.3.1 23.52
-
 catechol at pH 7.0 and 37°C Clonorchis sinensis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.1 copper contains copper Clonorchis sinensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.1 dihydroxyphenylalanine + O2 Clonorchis sinensis
-
 dihydroxyphenylalanine quinone + H2O
-
 ?
1.10.3.1 L-tyrosine + O2 Clonorchis sinensis
-
 dihydroxyphenylalanine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.1 Clonorchis sinensis
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.10.3.1 glycoprotein
-
 Clonorchis sinensis

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.1 Ni-NTA column chromatography Clonorchis sinensis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.3.1 egg intrauterine immature egg Clonorchis sinensis
-
1.10.3.1 vitelline gland
-
 Clonorchis sinensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.1 2-methylhydroquinone + O2 low activity Clonorchis sinensis ?
-
 ?
1.10.3.1 4-methylcatechol + O2 highest activity Clonorchis sinensis ?
-
 ?
1.10.3.1 catechol + O2
-
 Clonorchis sinensis ?
-
 ?
1.10.3.1 dihydroxyphenylalanine + O2
-
 Clonorchis sinensis dihydroxyphenylalanine quinone + H2O
-
 ?
1.10.3.1 dopamine + O2
-
 Clonorchis sinensis ?
-
 ?
1.10.3.1 hydroquinone + O2 low activity Clonorchis sinensis ?
-
 ?
1.10.3.1 L-DOPA + O2
-
 Clonorchis sinensis ?
-
 ?
1.10.3.1 L-tyrosine + O2
-
 Clonorchis sinensis dihydroxyphenylalanine + H2O
-
 ?
1.10.3.1 additional information the enzyme shows minimal activity toward monophenol compounds such as tyramine, tyrosine and tyrosine methyl ester Clonorchis sinensis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.1 TYR3 isoform Clonorchis sinensis
1.10.3.1 tyrosinase
-
 Clonorchis sinensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.3.1 heme
-
 Clonorchis sinensis

General Information

EC Number General Information Comment Organism
1.10.3.1 physiological function the enzyme is essential for Clonorchis sinensis reproduction Clonorchis sinensis