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Literature summary extracted from

  • Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.
    Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system (2013), Int. J. Med. Microbiol., 303, 190-200.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.9 expressed in Escherichia coli DH5alpha cells Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.9 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus NCTC 8325
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus RN4220
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O Staphylococcus aureus
-
 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O Staphylococcus aureus NCTC 8325
-
 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O Staphylococcus aureus RN4220
-
 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus NCTC 8325
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O Staphylococcus aureus RN4220
-
 S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus NCTC 8325
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus NCTC 8325
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus RN4220
-
 S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O Staphylococcus aureus RN4220
-
 adenine + S-methyl-5-thio-D-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.9 Staphylococcus aureus
-
-
-
3.2.2.9 Staphylococcus aureus NCTC 8325
-
-
-
3.2.2.16 Staphylococcus aureus
-
-
-
3.2.2.16 Staphylococcus aureus NCTC 8325
-
-
-
3.2.2.16 Staphylococcus aureus RN4220
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus NCTC 8325 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus RN4220 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O
-
 Staphylococcus aureus 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 5'-deoxyadenosine + H2O
-
 Staphylococcus aureus RN4220 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus NCTC 8325 S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus RN4220 S-ribosyl-L-homocysteine + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus RN4220 S-methyl-5-thio-D-ribose + adenine
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus adenine + S-methyl-5-thio-D-ribose
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus NCTC 8325 adenine + S-methyl-5-thio-D-ribose
-
 ?
3.2.2.16 S-methyl-5'-thioadenosine + H2O
-
 Staphylococcus aureus RN4220 adenine + S-methyl-5-thio-D-ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.9 methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
3.2.2.9 MTA/SAH nucleosidase
-
 Staphylococcus aureus
3.2.2.9 Pfs
-
 Staphylococcus aureus
3.2.2.16 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
3.2.2.16 methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
3.2.2.16 Pfs
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
3.2.2.9 physiological function the enzyme is essential for the virulence of Staphylococcus aureus and contributes to sepsis infection of mice. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for autoinducer-2 production Staphylococcus aureus
3.2.2.16 physiological function the enzyme is essential for the virulence of Staphylococcus aureus. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production Staphylococcus aureus
3.2.2.16 physiological function the enzyme is not essential for growth under nutrient-rich conditions, but is essential for AI-2 production. The enzyme is associated with Staphylococcus aureus subcutaneous abscess infection of mice Staphylococcus aureus