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Literature summary extracted from

  • Paulus, J.K.; Foerster, K.; Groth, G.
    Direct and selective small-molecule inhibition of photosynthetic PEP carboxylase: New approach to combat C4 weeds in arable crops (2014), FEBS Lett., 588, 2101-2106.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.31 expressed in Escherichia coli strains BL21(DE) and BL21-Gold(DE) Flaveria pringlei
4.1.1.31 expressed in Escherichia coli strains BL21(DE) and BL21-Gold(DE) Flaveria trinervia

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.31 (+)-catechin
-
 Flaveria pringlei
4.1.1.31 (+)-catechin
-
 Flaveria trinervia
4.1.1.31 2-(4-methoxyphenyl)-3-phenyl-quinoxaline
-
 Flaveria trinervia
4.1.1.31 AG 1433 i.e. 2-(3,4-dihydroxyphenyl)-6,7-dimethylquinoxaline Flaveria pringlei
4.1.1.31 AG 1433 i.e. 2-(3,4-dihydroxyphenyl)-6,7-dimethylquinoxaline Flaveria trinervia
4.1.1.31 epigallocatechin gallate
-
 Flaveria pringlei
4.1.1.31 epigallocatechin gallate
-
 Flaveria trinervia
4.1.1.31 additional information not inhibited by 2-(4-methoxyphenyl)-3-phenyl-quinoxaline Flaveria pringlei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.31 phosphate + oxaloacetate Flaveria pringlei
-
 phosphoenolpyruvate + HCO3-
-
 ?
4.1.1.31 phosphate + oxaloacetate Flaveria trinervia
-
 phosphoenolpyruvate + HCO3-
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.31 Flaveria pringlei Q01647
-
-
4.1.1.31 Flaveria trinervia P30694
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.31 His-Trap FF or HP column chromatography Flaveria pringlei
4.1.1.31 His-Trap FF or HP column chromatography Flaveria trinervia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.31 phosphate + oxaloacetate
-
 Flaveria pringlei phosphoenolpyruvate + HCO3-
-
 ?
4.1.1.31 phosphate + oxaloacetate
-
 Flaveria trinervia phosphoenolpyruvate + HCO3-
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.31 PEP carboxylase
-
 Flaveria pringlei
4.1.1.31 PEP carboxylase
-
 Flaveria trinervia
4.1.1.31 PEPC
-
 Flaveria pringlei
4.1.1.31 PEPC
-
 Flaveria trinervia

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.31 acetyl-CoA
-
 Flaveria pringlei
4.1.1.31 acetyl-CoA
-
 Flaveria trinervia

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.1.31 0.039
-
 at pH 8.0 and 25°C Flaveria trinervia AG 1433
4.1.1.31 0.065
-
 at pH 8.0 and 25°C Flaveria trinervia 2-(4-methoxyphenyl)-3-phenyl-quinoxaline
4.1.1.31 0.103
-
 at pH 8.0 and 25°C Flaveria trinervia (+)-catechin
4.1.1.31 0.307
-
 at pH 8.0 and 25°C Flaveria pringlei (+)-catechin