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Literature summary extracted from
- QM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis (2013), FEBS J., 280, 3120-3131.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.3.1 | D38E | the mutant gives similar free energies to the native enzyme, with catalytic constants approximately 200-300times less than in wild type enzyme | Comamonas testosteroni |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.3.1 | 5alpha-androstan-3,17-dione | - |
Comamonas testosteroni |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.3.1 | 5-Androstene-3,17-dione | Comamonas testosteroni | - |
4-Androstene-3,17-dione | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.3.1 | Comamonas testosteroni | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.3.1 | 5-Androstene-3,17-dione | - |
Comamonas testosteroni | 4-Androstene-3,17-dione | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.3.1 | DELTA5-3-keto steroid isomerase | - |
Comamonas testosteroni |
| 5.3.3.1 | ketosteroid isomerase | - |
Comamonas testosteroni |
| 5.3.3.1 | KSI | - |
Comamonas testosteroni |
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Release 2023.1 (January 2023)
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