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Literature summary extracted from

  • Filosa, R.; Peduto, A.; Aparoy, P.; Schaible, A.M.; Luderer, S.; Krauth, V.; Petronzi, C.; Massa, A.; de Rosa, M.; Reddanna, P.; Werz, O.
    Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase (2013), Eur. J. Med. Chem., 67, 269-279.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.34 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
-
 Homo sapiens
1.13.11.34 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 3'-nitrobiphenyl-2,4-diol
-
 Homo sapiens
1.13.11.34 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
-
 Homo sapiens
1.13.11.34 4-(1-benzothiophen-3-yl)benzene-1,3-diol
-
 Homo sapiens
1.13.11.34 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
-
 Homo sapiens
1.13.11.34 4-(naphthalen-2-ylmethyl)benzene-1,3-diol
-
 Homo sapiens
1.13.11.34 4-(thianthren-2-yl)benzene-1,3-diol
-
 Homo sapiens
1.13.11.34 4-benzylbenzene-1,3-diol
-
 Homo sapiens
1.13.11.34 4-hexylbenzene-1,3-diol
-
 Homo sapiens
1.13.11.34 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
-
 Homo sapiens
1.13.11.34 biphenyl-2,4-diol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonic acid + O2
-
 Homo sapiens (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 5-LO
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.34 37
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.00028
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.00058
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.00078
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0008
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0014
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0021
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(thianthren-2-yl)benzene-1,3-diol
1.13.11.34 0.0023
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0023
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(naphthalen-2-ylmethyl)benzene-1,3-diol
1.13.11.34 0.0028
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens biphenyl-2,4-diol
1.13.11.34 0.0028
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-hexylbenzene-1,3-diol
1.13.11.34 0.003
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hexyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0032
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(thianthren-2-yl)benzene-1,3-diol
1.13.11.34 0.0042
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens biphenyl-2,4-diol
1.13.11.34 0.0046
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0046
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-hexylbenzene-1,3-diol
1.13.11.34 0.0063
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
1.13.11.34 0.0067
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-methoxy-5-(naphthalen-2-yloxy)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.0068
-
 pH not specified in the publication, 37°C, cell-based test system Homo sapiens 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
1.13.11.34 0.0074
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(naphthalen-2-ylmethyl)benzene-1,3-diol
1.13.11.34 0.009
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-benzylbenzene-1,3-diol
1.13.11.34 0.009
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-(dibenzo[b,d]furan-3-yl)-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-(3-nitrophenyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(1-benzothiophen-3-yl)benzene-1,3-diol
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-(dibenzo[b,d]furan-3-yl)benzene-1,3-diol
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 4-benzylbenzene-1,3-diol
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-based test system Homo sapiens 6-[(4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)methyl]naphthalene-2-carboxylic acid
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 1-(2,4-dihydroxyphenyl)-2-(naphthalen-2-yl)ethanone
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-benzyl-5-hydroxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 2-hydroxy-5-methoxy-3-(naphthalen-2-ylmethyl)cyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3'-nitrobiphenyl-2,4-diol
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-benzyl-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
1.13.11.34 0.01
-
 value above, pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 4-(1-benzothiophen-3-yl)benzene-1,3-diol
1.13.11.34 0.01
-
 value above,pH not specified in the publication, 37°C, cell-based test system Homo sapiens 3'-nitrobiphenyl-2,4-diol
1.13.11.34 0.011
-
 pH not specified in the publication, 37°C, cell-free based test system Homo sapiens 3-(decahydronaphthalen-2-ylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione