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Literature summary extracted from

  • Lobo, G.P.; Isken, A.; Hoff, S.; Babino, D.; von Lintig, J.
    BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway (2012), Development, 139, 2966-2977.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.71 4-oxo-N-(4-hydroxyphenyl)-all-trans-retinamide
-
 Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.71 mitochondrion
-
 Homo sapiens 5739
-
1.13.11.71 mitochondrion
-
 Danio rerio 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.71 Danio rerio
-
-
-
1.13.11.71 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.71 embryo bcdo2 is expressed in the developing zebrafish Danio rerio
-
1.13.11.71 T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.71 beta-carotene + O2
-
 Homo sapiens 10'-apo-carotenal + beta-ionone
-
 ?
1.13.11.71 beta-carotene + O2
-
 Danio rerio 10'-apo-carotenal + beta-ionone
-
 ?
1.13.11.71 canthaxanthin + O2
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.71 Bcdo2
-
 Homo sapiens
1.13.11.71 Bcdo2
-
 Danio rerio

General Information

EC Number General Information Comment Organism
1.13.11.71 malfunction knockdown of Bcdo2 by siRNA treatment in T47D cells enhances reactive oxygen species production upon carotenoid treatment. Bcdo2 siRNA-treated T47D cells show initiation of apoptosis evidenced by caspase 3 and PARP1 cleavage as established by immunoblot analyses Homo sapiens
1.13.11.71 malfunction targeted knockdown of BCDO2 results in anemia at larval stages. Marker gene analysis and staining for hemoglobin revealed that erythropoiesis is not impaired but that erythrocytes undergo apoptosis in BCDO2- deficient larvae Danio rerio
1.13.11.71 physiological function BCDO2 dictates apoptotic responses to carotenoids and synthetic retinoids in human cancer cells Homo sapiens