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Literature summary extracted from

  • Fang, Z.; Liu, Y.; Liu, J.; Sun, R.; Chen, H.; Gao, X.; Yao, W.
    Designing and engineering of a site-specific incorporation of a keto group in uricase (2011), Chem. Biol. Drug Des., 78, 353-360.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.7.3.3 pharmacology urate oxidase is a potential therapeutic protein in the prevention and treatment of tumor lysis syndrome and hyperuricemia. However, its severe immunogenicity limits its clinical application. Engineering site-specific modifications of keto groups in urate oxidase by using evolved Methanocaldococcus jannaschii aminoacyl-tRNA synthetase(s)/suppressor tRNA pairs reduces its antigenicity. The mutated uricase exhibits decreased antigenic properties, while its catalytic activities remain unchanged Methanocaldococcus jannaschii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.7.3.3 expression in Escherichia coli Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
1.7.3.3 Methanocaldococcus jannaschii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.7.3.3
-
 Methanocaldococcus jannaschii

Synonyms

EC Number Synonyms Comment Organism
1.7.3.3 Urate oxidase
-
 Methanocaldococcus jannaschii