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Literature summary extracted from

  • Desvergnes, S.; Courtiol-Legourd, S.; Daher, R.; Dabrowski, M.; Salmon, L.; Therisod, M.
    Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase (2012), Bioorg. Med. Chem., 20, 1511-1520.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.8 5-deoxy-5-malonyl-D-arabinonohydroxamic acid
-
 Escherichia coli
5.3.1.8 5-phospho-D-arabinonohydroxamic acid
-
 Escherichia coli
5.3.1.8 N,2,3,4,5-pentahydroxypentanamide
-
 Escherichia coli
5.3.1.9 5-deoxy-5-malonate-D-arabinonohydroxamic acid
-
 Saccharomyces cerevisiae
5.3.1.9 5-phospho-D-arabinonohydroxamic acid
-
 Saccharomyces cerevisiae
5.3.1.9 N,2,3,4,5-pentahydroxypentanamide
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.8 0.354
-
 D-mannose 6-phosphate in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
5.3.1.9 0.084
-
 D-glucose 6-phosphate in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate Escherichia coli
-
 D-Fructose 6-phosphate
-
 ?
5.3.1.9 D-glucose 6-phosphate Saccharomyces cerevisiae
-
 D-fructose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.8 Escherichia coli
-
-
-
5.3.1.9 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate
-
 Escherichia coli D-Fructose 6-phosphate
-
 ?
5.3.1.9 D-glucose 6-phosphate
-
 Saccharomyces cerevisiae D-fructose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.1.8 Phosphomannose isomerase
-
 Escherichia coli
5.3.1.8 PMI
-
 Escherichia coli
5.3.1.9 PGI
-
 Saccharomyces cerevisiae
5.3.1.9 Phosphoglucose isomerase
-
 Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.1.8 0.0008
-
 5-phospho-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
5.3.1.8 0.162
-
 5-deoxy-5-malonyl-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
5.3.1.8 10
-
 N,2,3,4,5-pentahydroxypentanamide in 50 mM HEPES buffer, pH 7.1, at 25°C Escherichia coli
5.3.1.9 0.00023
-
 5-phospho-D-arabinonohydroxamic acid in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae
5.3.1.9 5.54
-
 N,2,3,4,5-pentahydroxypentanamide in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.3.1.9 2.29
-
 in 50 mM HEPES buffer, pH 7.1, at 25°C Saccharomyces cerevisiae 5-deoxy-5-malonate-D-arabinonohydroxamic acid