EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.19.1 | 4-(1,2-benzoxazol-3-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(1H-indol-3-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | 15% inhibition at 0.001 mM | Rattus norvegicus | |
1.14.19.1 | 4-(2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(2,3-dihydro-1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(3,4-dihydroquinolin-1(2H)-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(5-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(6-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | 20% inhibition at 0.001 mM | Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxyacetyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(methylcarbamoyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | N-(4-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | N-(5-acetyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | 46% inhibition at 0.001 mM | Rattus norvegicus | |
1.14.19.1 | N-(5-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | N-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | - |
Rattus norvegicus | |
1.14.19.1 | N-[3-(methylcarbamoyl)phenyl]-4-(2-oxo-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | 7% inhibition at 0.001 mM | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.19.1 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.19.1 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.19.1 | stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.19.1 | SCD1 | - |
Rattus norvegicus |
1.14.19.1 | stearoyl-CoA desaturase-1 | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.14.19.1 | 0.008 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.014 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(6-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.018 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.02 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.02 | 2 | pH and temperature not specified in the publication | Rattus norvegicus | N-(5-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.026 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.029 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.052 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.082 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(5-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.088 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxymethyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.093 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(methylcarbamoyl)-1,3-thiazol-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.096 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-[5-(hydroxyacetyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]piperidine-1-carboxamide | |
1.14.19.1 | 0.14 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(1,2-benzoxazol-3-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.151 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(2,3-dihydro-1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
1.14.19.1 | 0.153 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(2,3-dihydro-1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.17 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-indol-1-yl)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide | |
1.14.19.1 | 0.204 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.347 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.491 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(3,4-dihydroquinolin-1(2H)-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.538 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-indol-1-yl)-N-(4-methyl-1,3-thiazol-2-yl)piperidine-1-carboxamide | |
1.14.19.1 | 0.682 | - |
pH and temperature not specified in the publication | Rattus norvegicus | N-(4-carbamoyl-1,3-thiazol-2-yl)-4-(6-fluoro-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxamide |