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Literature summary extracted from

  • Ma, J.; Gou, D.; Liang, L.; Liu, R.; Chen, X.; Zhang, C.; Zhang, J.; Chen, K.; Jiang, M.
    Enhancement of succinate production by metabolically engineered Escherichia coli with co-expression of nicotinic acid phosphoribosyltransferase and pyruvate carboxylase (2013), Appl. Microbiol. Biotechnol., 97, 6739-6747.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.4.21 expressed in Escherichia coli strains BA002, BA014, BA015, and BA016 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.21 45000
-
 x * 45000, SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O Escherichia coli
-
 beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Escherichia coli P18133
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.21 0.7
-
 recombinant enzyme from Escherichia coli strain BA002, pH and temperature not specified in the publication Escherichia coli
6.3.4.21 1.01
-
 recombinant enzyme from Escherichia coli strain BA015, pH and temperature not specified in the publication Escherichia coli
6.3.4.21 10.54
-
 recombinant enzyme from Escherichia coli strain BA014, pH and temperature not specified in the publication Escherichia coli
6.3.4.21 18.74
-
 recombinant enzyme from Escherichia coli strain BA016, pH and temperature not specified in the publication Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Escherichia coli beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.21 ? x * 45000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
6.3.4.21 EC 2.4.2.11 formerly Escherichia coli
6.3.4.21 NAPRTase
-
 Escherichia coli
6.3.4.21 nicotinic acid phosphoribosyltransferase
-
 Escherichia coli
6.3.4.21 pncB
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.21 ATP
-
 Escherichia coli