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Literature summary extracted from

  • Arai, T.; Arimura, Y.; Ishikura, S.; Kino, K.
    L-amino acid ligase from Pseudomonas syringae producing tabtoxin can be used for enzymatic synthesis of various functional peptides (2013), Appl. Environ. Microbiol., 79, 5023-5029.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.3.2.49 synthesis Lal is a promising enzyme to achieve cost-effective synthesis Pseudomonas syringae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.49 gene tabS, overexpression in Escherichia coli Pseudomonas syringae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.49 Mg2+ required Pseudomonas syringae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.49 ATP + an L-amino acid + an L-amino acid Pseudomonas syringae
-
 ADP + phosphate + L-aminoacyl-L-amino acid
-
 ?
6.3.2.49 ATP + an L-amino acid + an L-amino acid Pseudomonas syringae NBRC 14081
-
 ADP + phosphate + L-aminoacyl-L-amino acid
-
 ?
6.3.2.49 additional information Pseudomonas syringae the enzyme TabS shows very broad substrate specificity, overview ?
-
 ?
6.3.2.49 additional information Pseudomonas syringae NBRC 14081 the enzyme TabS shows very broad substrate specificity, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.49 Pseudomonas syringae Q842E2 gene tabS
-
6.3.2.49 Pseudomonas syringae NBRC 14081 Q842E2 gene tabS
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.49 ATP + an L-amino acid + an L-amino acid
-
 Pseudomonas syringae ADP + phosphate + L-aminoacyl-L-amino acid
-
 ?
6.3.2.49 ATP + an L-amino acid + an L-amino acid
-
 Pseudomonas syringae NBRC 14081 ADP + phosphate + L-aminoacyl-L-amino acid
-
 ?
6.3.2.49 ATP + beta-alanine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-beta-alanine
-
 ?
6.3.2.49 ATP + cis-4-hydroxy-L-proline + L-threonine
-
 Pseudomonas syringae ADP + phosphate + cis-4-hydroxy-L-prolyl-L-threonine
-
 ?
6.3.2.49 ATP + L-arginine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-arginine
-
 ?
6.3.2.49 ATP + L-arginine + L-phenylalanine
-
 Pseudomonas syringae ADP + phosphate + L-arginyl-L-phenylalanine
-
 ?
6.3.2.49 ATP + L-asparagine + L-glutamine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-asparagine + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-asparagine + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-leucine
-
 ?
6.3.2.49 ATP + L-asparagine + L-leucine
-
 Pseudomonas syringae NBRC 14081 ADP + phosphate + L-asparaginyl-L-leucine
-
 ?
6.3.2.49 ATP + L-asparagine + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-serine
-
 ?
6.3.2.49 ATP + L-asparagine + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-threonine
-
 ?
6.3.2.49 ATP + L-asparagine + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-asparaginyl-L-valine
-
 ?
6.3.2.49 ATP + L-aspartate + L-alanine
-
 Pseudomonas syringae ADP + phosphate + L-aspartyl-L-alanine
-
 ?
6.3.2.49 ATP + L-aspartate + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-aspartyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-aspartate + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-aspartyl-L-leucine
-
 ?
6.3.2.49 ATP + L-aspartate + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-aspartyl-L-methionine
-
 ?
6.3.2.49 ATP + L-azetidine-2-carboxylate + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-azetidine-2-carboxyl-L-threonine
-
 ?
6.3.2.49 ATP + L-glutamate + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-glutamate + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-glutamyl-L-methionine
-
 ?
6.3.2.49 ATP + L-glutamine + L-alanine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-alanine
-
 ?
6.3.2.49 ATP + L-glutamine + L-alanine
-
 Pseudomonas syringae NBRC 14081 ADP + phosphate + L-glutaminyl-L-alanine
-
 ?
6.3.2.49 ATP + L-glutamine + L-arginine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-arginine
-
 ?
6.3.2.49 ATP + L-glutamine + L-histidine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-histidine
-
 ?
6.3.2.49 ATP + L-glutamine + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-glutamine + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-leucine
-
 ?
6.3.2.49 ATP + L-glutamine + L-leucine
-
 Pseudomonas syringae NBRC 14081 ADP + phosphate + L-glutaminyl-L-leucine
-
 ?
6.3.2.49 ATP + L-glutamine + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-methionine
-
 ?
6.3.2.49 ATP + L-glutamine + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-serine
-
 ?
6.3.2.49 ATP + L-glutamine + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-threonine
-
 ?
6.3.2.49 ATP + L-glutamine + L-tryptophan
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-tryptophan
-
 ?
6.3.2.49 ATP + L-glutamine + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-glutaminyl-L-valine
-
 ?
6.3.2.49 ATP + L-isoleucine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-leucine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-leucine
-
 ?
6.3.2.49 ATP + L-leucine + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-leucyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-leucine + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-leucyl-L-serine
-
 ?
6.3.2.49 ATP + L-methionine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-methionine
-
 ?
6.3.2.49 ATP + L-phenylalanine + glycine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanylglycine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-alanine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-alanine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-arginine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-arginine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-asparagine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-asparagine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-glutamine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-histidine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-histidine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-leucine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-lysine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-lysine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-methionine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-phenylalanine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-phenylalanine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-proline
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-proline
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-serine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-threonine
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-tryptophan
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-tryptophan
-
 ?
6.3.2.49 ATP + L-phenylalanine + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-phenylalanyl-L-valine
-
 ?
6.3.2.49 ATP + L-pipecolic acid + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-pipecoloyl-L-threonine
-
 ?
6.3.2.49 ATP + L-proline + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-proline
-
 ?
6.3.2.49 ATP + L-proline + glycine
-
 Pseudomonas syringae ADP + phosphate + L-prolylglycine
-
 ?
6.3.2.49 ATP + L-proline + L-alanine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-alanine
-
 ?
6.3.2.49 ATP + L-proline + L-asparagine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-asparagine
-
 ?
6.3.2.49 ATP + L-proline + L-aspartate
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-aspartate
-
 ?
6.3.2.49 ATP + L-proline + L-glutamate
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-glutamate
-
 ?
6.3.2.49 ATP + L-proline + L-glutamine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-proline + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-proline + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-leucine
-
 ?
6.3.2.49 ATP + L-proline + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-methionine
-
 ?
6.3.2.49 ATP + L-proline + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-serine
-
 ?
6.3.2.49 ATP + L-proline + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-threonine
-
 ?
6.3.2.49 ATP + L-proline + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-prolyl-L-valine
-
 ?
6.3.2.49 ATP + L-threonine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-threonine
-
 ?
6.3.2.49 ATP + L-tryptophan + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-tryptophan
-
 ?
6.3.2.49 ATP + L-tryptophan + glycine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophylglycine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-alanine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-alanine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-arginine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-arginine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-asparagine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-asparagine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-aspartate
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-aspartate
-
 ?
6.3.2.49 ATP + L-tryptophan + L-glutamate
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-glutamate
-
 ?
6.3.2.49 ATP + L-tryptophan + L-glutamine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-histidine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-histidine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-leucine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-leucine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-lysine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-lysine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-methionine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-proline
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-proline
-
 ?
6.3.2.49 ATP + L-tryptophan + L-serine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-serine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-threonine
-
 ?
6.3.2.49 ATP + L-tryptophan + L-tryptophan
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-tryptophan
-
 ?
6.3.2.49 ATP + L-tryptophan + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-tryptophyl-L-valine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-arginine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-arginine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-glutamine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-glutamine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-histidine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-histidine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-isoleucine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-isoleucine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-methionine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-methionine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-phenylalanine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-phenylalanine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-proline
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-proline
-
 ?
6.3.2.49 ATP + L-tyrosine + L-threonine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-threonine
-
 ?
6.3.2.49 ATP + L-tyrosine + L-tryptophan
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-tryptophan
-
 ?
6.3.2.49 ATP + L-tyrosine + L-valine
-
 Pseudomonas syringae ADP + phosphate + L-tyrosyl-L-valine
-
 ?
6.3.2.49 ATP + L-valine + beta-alanine
-
 Pseudomonas syringae ADP + phosphate + beta-alanyl-L-valine
-
 ?
6.3.2.49 ATP + trans-4-hydroxy-L-proline + L-threonine
-
 Pseudomonas syringae ADP + phosphate + trans-4-hydroxy-L-prolyl-L-threonine
-
 ?
6.3.2.49 additional information the enzyme TabS shows very broad substrate specificity, overview Pseudomonas syringae ?
-
 ?
6.3.2.49 additional information the enzyme TabS shows very broad substrate specificity, overview Pseudomonas syringae NBRC 14081 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.49 L-amino acid ligase
-
 Pseudomonas syringae
6.3.2.49 LAL
-
 Pseudomonas syringae
6.3.2.49 TabS
-
 Pseudomonas syringae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.49 35
-
-
 Pseudomonas syringae

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
6.3.2.49 10 50 activity range, profile overview Pseudomonas syringae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.49 9 9.5
-
 Pseudomonas syringae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.3.2.49 7 10 activity range, profile overview Pseudomonas syringae

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.49 ATP
-
 Pseudomonas syringae