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Literature summary extracted from

  • Siemieniuch, M.J.; Jursza, E.; Kowalewski, M.P.; Majewska, M.; Skarzynski, D.J.
    Prostaglandin endoperoxide synthase 2 (PTGS2) and prostaglandins F2alpha and E2 synthases (PGFS and PGES) expression and prostaglandin F2alpha and E2 secretion following oestrogen and/or progesterone stimulation of the feline endometrium (2013), Reprod. Domest. Anim., 48, 72-78.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.188 gene PGFS, DNA and amino acid sequence determination and analysis Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.188 prostaglandin H2 + NADP+ Felis catus
-
 prostaglandin F2alpha + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.188 Felis catus E2IGW3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.188 uterine endometrium at oestrus and mid and late phases of pseudopregnancy Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.188 prostaglandin H2 + NADP+
-
 Felis catus prostaglandin F2alpha + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.188 9,11-endoperoxidase reductase
-
 Felis catus
1.1.1.188 PGF2alpha synthase
-
 Felis catus
1.1.1.188 PGFS
-
 Felis catus
1.1.1.188 prostaglandin F2alpha synthase
-
 Felis catus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.188 NADP+
-
 Felis catus

Expression

EC Number Organism Comment Expression
1.1.1.188 Felis catus treatment with estradiol and/or progesterone affects neither PGF2alpha secretion nor enzyme PGFS expression at any phase after 12 h of culture, while related enzymes PG-endoperoxide synthase (PTGS2) and PGE2 synthase (PGES) are both upregulated by estradiol and progesterone during pseudopregnancy additional information
1.1.1.188 Felis catus expression is significantly up-regulated by oestradiol plus progesterone at oestrus and the mid phase of pseudopregnancy and is also up-regulated by a single treatment with progesterone at late pseudopregnancy. Simultaneous incubation with oestradiol and progesterone up-regulates prostaglandin-endoperoxide synthase PTGS2 gene expression at oestrus and mid-luteal phase. Treatment with oestradiol and /or progesterone affects neither prostaglandin F2alpha secretion nor prostaglandin F2alpha synthase expression at any phase after 12 h of culture up

General Information

EC Number General Information Comment Organism
1.1.1.188 metabolism the prostaglandin H2 (PGH2) is the common precursor of prostaglandin F2alpha (PGF2alphha) and prostaglandin E2 (PGE2). PGH2 is converted into one of the active prostaglandins by a specific terminal synthase, such as PGE2 synthase (PGES), which is responsible for PGE2 production or 9,11-endoperoxidase reductase, which has PGF2alpha synthase (PGFS) activity Felis catus