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Literature summary extracted from

  • Tandogan, B.; Ulusu, N.N.
    Comparative in vitro effects of some metal ions on bovine kidney cortex glutathione reductase (2010), Prep. Biochem. Biotechnol., 40, 405-411.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 Cd2+ noncompetitive inhibition with respect to both glutathione disulfide and NADPH Bos taurus
1.8.1.7 Ni2+ noncompetitive inhibition with respect to glutathione disulfide and uncompetitive with respect to NADPH Bos taurus
1.8.1.7 Zn2+ noncompetitive inhibition with respect to both glutathione disulfide and NADPH Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+ Bos taurus
-
 glutathione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 renal cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Bos taurus glutathione + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.027
-
 pH and temperature not specified in the publication Bos taurus Cd2+
1.8.1.7 0.8
-
 pH and temperature not specified in the publication Bos taurus Ni2+
1.8.1.7 1
-
 pH and temperature not specified in the publication Bos taurus Zn2+