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Literature summary extracted from

  • Collakova, E.; DellaPenna, D.
    Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis (2001), Plant Physiol., 127, 1113-1124.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.115 expression in Escherichia coli Arabidopsis thaliana
2.5.1.115 expression in Escherichia coli Synechocystis sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.115 membrane membrane-bound Arabidopsis thaliana 16020
-
2.5.1.115 membrane membrane-bound Synechocystis sp. 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.115 phytyl diphosphate + homogentisate Arabidopsis thaliana the enzyme is involved in the biosynthesis of the vitamin E tocopherols diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate Synechocystis sp. the enzyme is involved in the biosynthesis of the vitamin E tocopherols diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.115 Arabidopsis thaliana Q8VWJ1
-
-
2.5.1.115 Synechocystis sp. P73726
-
-
2.5.1.116 Synechocystis sp. P73726
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.115 geranylgeranyl diphosphate + homogentisate about 18% of the activity with phythyldiphosphate Synechocystis sp. diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 geranylgeranyl diphosphate + homogentisate
-
 Synechocystis sp. ?
-
 ?
2.5.1.115 additional information no substrate: solanesyl diphosphate Synechocystis sp. ?
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate preferred substrate Synechocystis sp. diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate the enzyme is involved in the biosynthesis of the vitamin E tocopherols Arabidopsis thaliana diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate the enzyme is involved in the biosynthesis of the vitamin E tocopherols Synechocystis sp. diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate no activity with geranylgeranyl diphosphate, no activity with solanesyl diphosphate Arabidopsis thaliana diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate phytyl diphosphate and homogentisate are the preferred substrates in vito, no activity with solanesyl diphosphate Synechocystis sp. diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.116 geranylgeranyl diphosphate + homogentisate about 18% of the activity with phythyl diphosphate Synechocystis sp. diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2
-
 ?
2.5.1.116 additional information no substrate: solanesyl diphosphate Synechocystis sp. ?
-
 ?
2.5.1.116 phytyl diphosphate + homogentisate preferred substrate Synechocystis sp. diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.115 HPT
-
 Arabidopsis thaliana
2.5.1.115 SynHPT
-
 Synechocystis sp.
2.5.1.115 VTE2
-
 Arabidopsis thaliana
2.5.1.115 VTE2
-
 Synechocystis sp.

General Information

EC Number General Information Comment Organism
2.5.1.115 malfunction disruption of Synechocystis sp. PCC 6803 HPT function causes an absence of tocopherols without affecting plastoquinone-9 levels, indicating that separate polyprenyltransferases exist for tocopherol and plastoquinone synthesis in Synechocystis sp. PCC 6803 Synechocystis sp.
2.5.1.115 physiological function the enzyme is involved in the biosynthesis of the vitamin E tocopherols. Tocopherol functions to limit lipid oxidation during seed desiccation, quiescence and germination and early seedling development. Protects thylakoid membrane lipids from photooxidation and is required for low-temperature adaptation Arabidopsis thaliana
2.5.1.115 physiological function the enzyme is involved in the biosynthesis of the vitamin E tocopherols. Tocopherol functions to limit lipid oxidation during seed desiccation, quiescence and germination and early seedling development. Protects thylakoid membrane lipids from photooxidation and is required for low-temperature adaptation Synechocystis sp.
2.5.1.115 physiological function SLR1736 gene disruption does not lead to significant differences in cellular plastoquinone, phylloquinone, and chlorophyll levels, but causes absence of tocopherols without affecting plastoquinone-9 levels Synechocystis sp.
2.5.1.116 physiological function SLR1736 gene disruption does not lead to significant differences in cellular plastoquinone, phylloquinone, and chlorophyll levels, but causes absence of tocopherols without affecting plastoquinone-9 levels Synechocystis sp.