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Literature summary extracted from
- Silencing of flavanone-3-hydroxylase in apple (Malus x domestica Borkh.) leads to accumulation of flavanones, but not to reduced fire blight susceptibility (2012), Plant Physiol. Biochem., 51, 18-25.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.9 | gene fht, transcription profiling and quantitative real-time PCR expression analysis | Malus domestica |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.11.9 | additional information | F3H silencing by fht antisense transgenic apple clones construction, diverse transgenic lines, phenotypes, overview | Malus domestica |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.9 | prohexadione-Ca | an enzyme inhibitor for 2-oxoglutarate dependent dioxygenases, used as a growth retardant and for control of secondary fire blight, Erwinia amylovora, of apple leaves | Malus domestica |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.9 | Fe2+ | required | Malus domestica | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.9 | a flavanone + 2-oxoglutarate + O2 | Malus domestica | - |
a dihydroflavonol + succinate + CO2 | - |
? | |
| 1.14.11.9 | eriodyctiol + 2-oxoglutarate + O2 | Malus domestica | - |
dihydroquercetin + succinate + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.9 | Malus domestica | - |
cv. Pinova, gene fht | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.9 | a flavanone + 2-oxoglutarate + O2 | - |
Malus domestica | a dihydroflavonol + succinate + CO2 | - |
? | |
| 1.14.11.9 | eriodyctiol + 2-oxoglutarate + O2 | - |
Malus domestica | dihydroquercetin + succinate + CO2 | - |
? | |
| 1.14.11.9 | naringenin + 2-oxoglutarate + O2 | - |
Malus domestica | dihydrokaempferol + succinate + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.9 | F3H | - |
Malus domestica |
| 1.14.11.9 | FHT | - |
Malus domestica |
| 1.14.11.9 | flavanone-3-hydroxylase | - |
Malus domestica |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.9 | 30 | - |
assay at | Malus domestica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.9 | 7.25 | - |
assay at | Malus domestica |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.11.9 | Malus domestica | downregulation of flavanone 4-reductase leads to upregulation of other flavanoid pathway genes, inclunding the flavanone 3-hydroxylase, feedback regulation of flavonoid gene expression, overview | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.11.9 | evolution | the enzyme belongs to the 2-oxoglutarate-dependant dioxygenases | Malus domestica |
| 1.14.11.9 | malfunction | silencing of flavanone-3-hydroxylase leads to an accumulation of flavanones in leaves, but in contrast not to the formation of 3-deoxyflavonoids. In prohexadione-Ca treated leaves the 3-deoxyflavonoid luteoforol is formed from accumulating flavanones, acting as an antimicrobial compound against the fire blight pathogen Erwinia amylovora. Inducible resistance to fire blight by prohexadione-Ca is not observed with the antisense flavanone-3-hydroxylase apple plants | Malus domestica |
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