EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.1.1.270 | additional information | erg27 mutation and erg27 polymorphism in different strains and fenhexamid phenotypes, overview | Botrytis cinerea |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.270 | acetonitrile | - |
Botrytis cinerea | |
1.1.1.270 | dimethyl sulfoxide | - |
Botrytis cinerea | |
1.1.1.270 | ethanol | - |
Botrytis cinerea | |
1.1.1.270 | fenhexamid | Erg27 mutations causing amino acid substitutions in or near the transmembrane domain strongly decrease the affinity of fenhexamid for 3-ketoreductase. Sterol 3-ketoreductase sensitivity to fenhexamid in the various fungal strains, overview | Botrytis cinerea | |
1.1.1.270 | propan-2-ol | - |
Botrytis cinerea |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.270 | microsome | - |
Botrytis cinerea | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.270 | Mg2+ | required | Botrytis cinerea |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.270 | Botrytis cinerea | - |
gene erg27 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.270 | mycelium | - |
Botrytis cinerea | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.270 | 4alpha-methylfecosterone + NADPH + H+ | - |
Botrytis cinerea | 4alpha-methylfecosterol + NADP+ | 4alpha-methylfecosterol is further converted to ergosterol | ? | |
1.1.1.270 | fecosterone + NADPH + H+ | - |
Botrytis cinerea | fecosterol + NADP+ | - |
? | |
1.1.1.270 | additional information | substrate for 3-ketoreductase in the first sterol C-4 demethylation cycle is 4alpha-methylfecosterone, whereas that for the second C-4 demethylation cycle is fecosterone | Botrytis cinerea | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.270 | sterol 3-ketoreductase | - |
Botrytis cinerea |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.270 | 30 | - |
assay at | Botrytis cinerea |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.270 | 7 | - |
assay at | Botrytis cinerea |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.270 | NADPH | - |
Botrytis cinerea |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.270 | malfunction | two Botrytis cinerea fenhexamid-resistant phenotypes both result from mutations in the erg27 gene encoding 3-ketoreductase. Erg27 mutations causing amino acid substitutions in or near the transmembrane domain strongly decrease the affinity of fenhexamid for 3-ketoreductase | Botrytis cinerea |
1.1.1.270 | metabolism | the 3-ketoreductase is involved at C-4 demethylation steps during ergosterol biosynthesis. Steryl compound contents of Botrytis strains with different fenhexamid susceptibilities, overview | Botrytis cinerea |