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Literature summary extracted from

  • Dobrovolska, O.; Rychkov, G.; Shumilina, E.; Nerinovski, K.; Schmidt, A.; Shabalin, K.; Yakimov, A.; Dikiy, A.
    Structural insights into interaction between mammalian methionine sulfoxide reductase B1 and thioredoxin (2012), J. Biomed. Biotechnol., 2012, 586539.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 expressed in Escherichia coli ER2566 cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin Mus musculus MsrB is stereospecific for the R-epimer of methionine sulfoxide L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Mus musculus Q9JLC3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.12 Ni-NTA column chromatography, and gel filtration Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 dabsyl-L-methionine (R)-sulfoxide + thioredoxin
-
 Mus musculus dabsyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is stereospecific for the R-epimer of methionine sulfoxide Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine sulfoxide reductase B1
-
 Mus musculus
1.8.4.12 MSRB1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 thioredoxin
-
 Mus musculus