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Literature summary extracted from
- Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A (2012), J. Biol. Chem., 287, 25589-25595.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.11 | cytosol | the myristoylated enzyme form is found in cytosol | Mus musculus | 5829 | - |
| 1.8.4.11 | membrane | - |
Mus musculus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + dithiothreitol | Mus musculus | the myristoylated enzyme form reduces methionine sulfoxide in protein much faster than the nonmyristoylated form | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Mus musculus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | lipoprotein | myristoylation | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | apolipoprotein A-I + dithiothreitol | the myristoylated enzyme reduces the methionine sulfoxides in apolipoprotein A-I four times faster than nonmyristoylated enzyme | Mus musculus | ? | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + dithiothreitol | the myristoylated enzyme form reduces methionine sulfoxide in protein much faster than the nonmyristoylated form | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | methionine sulfoxide reductase A | - |
Mus musculus |
| 1.8.4.11 | MsrA | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | thioredoxin | - |
Mus musculus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | metabolism | methionine sulfoxide reductase A is an essential enzyme in the antioxidant system which scavenges reactive oxygen species through cyclic oxidation and reduction of methionine and methionine sulfoxide | Mus musculus |
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Release 2023.1 (January 2023)
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