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Literature summary extracted from

  • Wang, C.; Kane, M.A.; Napoli, J.L.
    Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes (2011), J. Biol. Chem., 286, 6542-6553.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.36 cytosol isoforms Raldh1 and Raldh2 Rattus norvegicus 5829
-
1.2.1.36 nucleus isoform Raldh1 Rattus norvegicus 5634
-
1.2.1.36 perinuclear space isoform Raldh2 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O Rattus norvegicus
-
 retinoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 astrocyte
-
 Rattus norvegicus
-
1.2.1.36 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 retinal + NAD+ + H2O
-
 Rattus norvegicus retinoate + NADH + H+
-
 ?
1.2.1.36 retinol + NAD+ + H2O
-
 Rattus norvegicus all-trans-retinoic acid + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 RalDH1 isoform Rattus norvegicus
1.2.1.36 RALDH2 isoform Rattus norvegicus
1.2.1.36 retinaldehyde dehydrogenases
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.2.1.36 metabolism both isoforms Raldh1 and -2 contribute to atRA biosynthesis in hippocampus astrocytes Rattus norvegicus