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Literature summary extracted from

  • Khanna, M.; Chen, C.H.; Kimble-Hill, A.; Parajuli, B.; Perez-Miller, S.; Baskaran, S.; Kim, J.; Dria, K.; Vasiliou, V.; Mochly-Rosen, D.; Hurley, T.D.
    Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases (2011), J. Biol. Chem., 286, 43486-43494.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.3 isoform ALDH2, using 100 mM Na-ACES buffer, pH 6.4-6.6, 100 mM guanidine-HCl, 10 mM MgCl2, and 4 mM dithiothreitol and 16-17% (w/v) PEG 6000 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
-
 Homo sapiens
1.2.1.3 3-(1-azepanyl)-1-phenyl-1-propanone
-
 Homo sapiens
1.2.1.3 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
-
 Homo sapiens
1.2.1.3 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 ammonium sulfate precipitation, column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 propionaldehyde + NAD+ + H2O
-
 Homo sapiens propionate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALD1A1 isoform Homo sapiens
1.2.1.3 ALDH2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.3 0.0022
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(1-azepanyl)-1-phenyl-1-propanone
1.2.1.3 0.0025
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
1.2.1.3 0.0054
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
1.2.1.3 0.0064
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
1.2.1.3 0.0068
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
1.2.1.3 0.0079
-
 isoform ALDH1A1, pH and temperature not specified in the publication Homo sapiens 3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
1.2.1.3 0.0083
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
1.2.1.3 0.0086
-
 isoform ALDH2, pH and temperature not specified in the publication Homo sapiens 3-(1-azepanyl)-1-phenyl-1-propanone