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Literature summary extracted from

  • Thompson, E.A.Jr.; Siiteri, P.K.
    The involvement of human placental microsomal cytochrome P-450 in aromatization (1974), J. Biol. Chem., 249, 5373-5378.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.14 19-hydroxyandrost-4-ene-3,17-dione competitive with substrates androst-4-ene-3,17-dione and 19-oxoandrost-4-ene-3,17-dione Homo sapiens
1.14.14.14 19-nortestosterone competitive inhibitor of both aromatization and cytochrome P450 binding of androst-4-ene-3,17-dione Homo sapiens
1.14.14.14 19-oxoandrost-4-ene-3,17-dione competitive with substrates androst-4-ene-3,17-dione and 19-hydroxyandrost-4-ene-3,17-dione Homo sapiens
1.14.14.14 Aminoglutethimide 0.005 mM, 54% residual activity Homo sapiens
1.14.14.14 androst-4-ene-3,17-dione competitive inhibitor of both aromatization and cytochrome P450 binding of 19-nortestosterone Homo sapiens
1.14.14.14 diethylaminoethyl-2,2-diphenylvalerate 0.05 mM, 64% residual activity Homo sapiens
1.14.14.14 KCN 5 mM, 80% residual activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.14 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.14 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.14 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.14 additional information the rate of entry of the first electron into the oxidized P450 substrate complex may be rate limiting in the aromatization of C19 but not C18 steroids Homo sapiens ?
-
 ?