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Literature summary extracted from

  • Grigoriev, I.; Senin, I.; Tikhomirova, N.; Komolov, K.; Permyakov, S.; Zerni, E.; Koch, K.; Philippov, P.
    Synergetic effect of recoverin and calmodulin on regulation of rhodopsin kinase (2012), Front. Mol. Neurosci., 5, 28.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14 expressed as a GST-fusion protein Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.14 DELTA1-102 deletion fragment containing the first 102 amino acids interacts with calmodulin Bos taurus
2.7.11.14 DELTA1-25 recoverin interacts with the rhodopsin fragment containing the first 25 amino acids of the enzyme. Calmodulin does not interact with this fragment Bos taurus
2.7.11.14 DELTA102-183 deletion fragment containing only amino acids 102-183 shows a very high interaction with calmodulin Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.14 Calmodulin the high affinity calmodulin binding site is localized within a stretch of amino acid residues V150-K175 in the N-terminal regulatory region of rhodopsin kinase. The inhibitory effect of calmodulin and recoverin on rhodopsin kinase activity is synergetic Bos taurus
2.7.11.14 recoverin the inhibitory effect of calmodulin and recoverin on rhodopsin kinase activity is synergetic Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Ca2+ regulation of the rhodopsin activity by recoverin and calmodulin is Ca2+-dependent Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + rhodopsin
-
 Bos taurus ADP + phosphorylated rhodopsin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.14 GRK1
-
 Bos taurus
2.7.11.14 rhodopsin kinase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.14 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.14 7.5
-
 assay at Bos taurus