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Literature summary extracted from

  • Reybier, K.; Perio, P.; Ferry, G.; Bouajila, J.; Delagrange, P.; Boutin, J.A.; Nepveu, F.
    Insights into the redox cycle of human quinone reductase 2 (2011), Free Radic. Res., 45, 1184-1195.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.5.1 expression of His-tagged OR2 in Spodoptera frugiperda Sf9 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 dicoumarol
-
 Homo sapiens
1.10.5.1 Melatonin
-
 Homo sapiens
1.10.5.1 resveratrol
-
 Homo sapiens
1.10.5.1 S29434 synthetic compound, complete inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.5.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q Homo sapiens natural substrate nicotinamide riboside, NRH 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
-
 ?
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + menadione Homo sapiens natural substrate nicotinamide riboside, NRH 1-(beta-D-ribofuranosyl)nicotinamide + menadiol
-
 ?
1.10.5.1 additional information Homo sapiens the enzyme catalyzes the reduction of quinones, such as menadione and co-enzyme Q ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.5.1 recombinant His-tagged OR2 from Spodoptera frugiperda Sf9 cells by nickel affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone
-
 Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone
-
 ?
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + co-enzyme Q natural substrate nicotinamide riboside, NRH Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + reduced co-enzyme Q
-
 ?
1.10.5.1 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + menadione natural substrate nicotinamide riboside, NRH Homo sapiens 1-(beta-D-ribofuranosyl)nicotinamide + menadiol
-
 ?
1.10.5.1 additional information the enzyme catalyzes the reduction of quinones, such as menadione and co-enzyme Q Homo sapiens ?
-
 ?
1.10.5.1 additional information QR2 produces free radicals with pro-drug CB1954, i.e. 5-(aziridin-1-yl)-2,4-dinitrobenzamide. The anti-cancer pro-drug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) is transformed into a potent cytotoxic drug upon reduction of its 4-nitro group to a 4-hydroxylamine by quinone reductases or nitroreductase Homo sapiens ?
-
 ?
1.10.5.1 N-benzyldihydronicotinamide + a quinone synthetic substrate Homo sapiens N-benzylnicotinamide + a hydroquinone
-
 ?

Subunits

EC Number Subunits Comment Organism
1.10.5.1 homodimer the enzyme forms homodimers with two independent and equivalent active sites each containing a FAD cofactor Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 NRH:QR2
-
 Homo sapiens
1.10.5.1 QR2
-
 Homo sapiens
1.10.5.1 quinone reductase 2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.10.5.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.10.5.1 8.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD 1 molecule per subunit, binds to the active site of each subunit Homo sapiens

General Information

EC Number General Information Comment Organism
1.10.5.1 additional information comparison of isoenzymes Qr1 and QR2, overview Homo sapiens