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Literature summary extracted from
- Stereospecific oxidation of calmodulin by methionine sulfoxide reductase A (2013), Free Radic. Biol. Med., 61C, 257-264.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | expressed in Escherichia coli BL21(DE3) cells | Mus musculus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | C72A | active-site mutant | Mus musculus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.4.11 | 0.197 | - |
Calmodulin | myristoylated enzyme, in 20 mM Tris-HCl, pH 7.5, 1 mM CaCl2, at 37°C | Mus musculus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | Ni-NTA column chromatography | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | alpha-synuclein + thioredoxin disulfide + H2O | Met1 and Met5 within alpha-synuclein are oxidized to (S)-methionine sulfoxide | Mus musculus | ? | - |
? | |
| 1.8.4.11 | alpha1-antitrypsin + thioredoxin disulfide + H2O | Met358 within alpha1-antitrypsin is oxidized to (S)-methionine sulfoxide | Mus musculus | ? | - |
? | |
| 1.8.4.11 | calmodulin + thioredoxin disulfide + H2O | Met77 within calmodulin is oxidized to (S)-methionine sulfoxide | Mus musculus | ? | - |
r | |
| 1.8.4.11 | additional information | no oxidation or reduction of L-methionine in 14-3-3 zeta/delta protein, actin, alpha-crystallin A, alpha-crystallin B, apolipoprotein A, glutamine synthetase, peroxiredoxin 6, and thioredoxin | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | methionine sulfoxide reductase A | - |
Mus musculus |
| 1.8.4.11 | MsrA | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | thioredoxin | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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