Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Saleh, M.C.; McConkey, S.
    NADH-dependent cytochrome b5 reductase and NADPH methemoglobin reductase activity in the erythrocytes of Oncorhynchus mykiss (2012), Fish Physiol. Biochem., 38, 1807-1813.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.2 membrane bound Oncorhynchus mykiss 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH Canis lupus familiaris
-
 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH Equus caballus
-
 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH Oncorhynchus mykiss
-
 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH Felis sp.
-
 2 ferrocytochrome b5 + NAD+ + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.2 Canis lupus familiaris
-
-
-
1.6.2.2 Equus caballus
-
-
-
1.6.2.2 Felis sp.
-
-
-
1.6.2.2 Oncorhynchus mykiss
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.2 erythrocyte
-
 Canis lupus familiaris
-
1.6.2.2 erythrocyte
-
 Equus caballus
-
1.6.2.2 erythrocyte
-
 Felis sp.
-
1.6.2.2 erythrocyte nucleated Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.2.2 additional information
-
 enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Canis lupus familiaris
1.6.2.2 additional information
-
 enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Equus caballus
1.6.2.2 additional information
-
 enzyme activity in erythrocytes of mammalian enzymes and rainbow trout, overview Felis sp.
1.6.2.2 additional information
-
 enzyme activity in erythrocytes of rainbow trout compared to mammalian enzymes, overview Oncorhynchus mykiss

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH
-
 Canis lupus familiaris 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH
-
 Equus caballus 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH
-
 Oncorhynchus mykiss 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
1.6.2.2 2 ferricytochrome b5 + NADH
-
 Felis sp. 2 ferrocytochrome b5 + NAD+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.2 cb5r
-
 Canis lupus familiaris
1.6.2.2 cb5r
-
 Equus caballus
1.6.2.2 cb5r
-
 Oncorhynchus mykiss
1.6.2.2 cb5r
-
 Felis sp.
1.6.2.2 NADH-dependent cytochrome b5 reductase
-
 Canis lupus familiaris
1.6.2.2 NADH-dependent cytochrome b5 reductase
-
 Equus caballus
1.6.2.2 NADH-dependent cytochrome b5 reductase
-
 Oncorhynchus mykiss
1.6.2.2 NADH-dependent cytochrome b5 reductase
-
 Felis sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.2 NADH dependent on Canis lupus familiaris
1.6.2.2 NADH dependent on Equus caballus
1.6.2.2 NADH dependent on Oncorhynchus mykiss
1.6.2.2 NADH dependent on Felis sp.

General Information

EC Number General Information Comment Organism
1.6.2.2 metabolism the quantity of methemoglobin is kept in balance by an efficient redox system within erythrocytes involving the enzyme, overview Oncorhynchus mykiss
1.6.2.2 physiological function methemoglobin in rainbow trout erythrocytes can be reduced by NADH-dependent cytochrome b5 reductase, i.e. CB5R, or NADPH-dependent methemoglobin reductase. The nucleated red blood cells of rainbow trout use membrane-bound CB5R to reduce methemoglobin Oncorhynchus mykiss