EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.89 | expression in Escherichia coli | Picrophilus torridus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.89 | D-glyceraldehyde | slight substrate inhibition, 25% inhibition at 2 mM | Picrophilus torridus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.89 | 0.06 | - |
D-glyceraldehyde | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 0.2 | - |
D-glyceraldehyde | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 0.36 | - |
NADP+ | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 0.42 | - |
NADP+ | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 5.1 | - |
D-glycerate | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 11.1 | - |
glycolaldehyde | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 12.3 | - |
glycolaldehyde | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 18.3 | - |
D-glycerate | pH 6.9, 58°C | Thermoplasma acidophilum |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 54700 | - |
2 * 54700, calculated from sequence | Thermoplasma acidophilum |
1.2.1.89 | 55200 | - |
2 * 55200, calculated from sequence | Picrophilus torridus |
1.2.1.89 | 56000 | - |
2 * 56000, SDS-PAGE | Thermoplasma acidophilum |
1.2.1.89 | 56000 | - |
2 * 56000, SDS-PAGE | Picrophilus torridus |
1.2.1.89 | 115000 | - |
gel filtration | Picrophilus torridus |
1.2.1.89 | 120000 | - |
gel filtration | Thermoplasma acidophilum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | Thermoplasma acidophilum | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | Picrophilus torridus | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | Thermoplasma acidophilum JCM 9062 | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | Picrophilus torridus DSM 9790 | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | D-glycerate + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.89 | Picrophilus torridus | Q6L285 | - |
- |
1.2.1.89 | Picrophilus torridus DSM 9790 | Q6L285 | - |
- |
1.2.1.89 | Thermoplasma acidophilum | Q9HK01 | - |
- |
1.2.1.89 | Thermoplasma acidophilum JCM 9062 | Q9HK01 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.89 | - |
Thermoplasma acidophilum |
1.2.1.89 | - |
Picrophilus torridus |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 6 | - |
pH 6.9, 58°C | Picrophilus torridus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Thermoplasma acidophilum | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Picrophilus torridus | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | completely inactive with NAD+ | Thermoplasma acidophilum | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | completely inactive with NAD+ | Picrophilus torridus | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Thermoplasma acidophilum JCM 9062 | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | completely inactive with NAD+ | Thermoplasma acidophilum JCM 9062 | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Picrophilus torridus DSM 9790 | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde + NADP+ + H2O | completely inactive with NAD+ | Picrophilus torridus DSM 9790 | D-glycerate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde 3-phosphate + NADP+ + H2O | catalytic efficiency (kcat/Km) for D-glyceraldehyde 3-phosphate is 1.4% compared to the catalytic efficiency with D-glyceraldehyde | Picrophilus torridus | D-glycerate 3-phosphate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde 3-phosphate + NADP+ + H2O | catalytic efficiency (kcat/Km) for glyceraldehyde 3-phosphate is less than 1% compared to the catalytic efficiency with D-glyceraldehyde | Thermoplasma acidophilum | D-glycerate 3-phosphate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde 3-phosphate + NADP+ + H2O | catalytic efficiency (kcat/Km) for glyceraldehyde 3-phosphate is less than 1% compared to the catalytic efficiency with D-glyceraldehyde | Thermoplasma acidophilum JCM 9062 | D-glycerate 3-phosphate + NADPH + H+ | - |
? | |
1.2.1.89 | D-glyceraldehyde 3-phosphate + NADP+ + H2O | catalytic efficiency (kcat/Km) for D-glyceraldehyde 3-phosphate is 1.4% compared to the catalytic efficiency with D-glyceraldehyde | Picrophilus torridus DSM 9790 | D-glycerate 3-phosphate + NADPH + H+ | - |
? | |
1.2.1.89 | glycolaldehyde + NADP+ | catalytic efficiency (kcat/Km) for glycolaldehyde is 1% compared to the catalytic efficiency with D-glyceraldehyde | Picrophilus torridus | glycolate + NADPH + H+ | - |
? | |
1.2.1.89 | glycolaldehyde + NADP+ | catalytic efficiency (kcat/Km) for glycolaldehyde is about 2% compared to the catalytic efficiency with D-glyceraldehyde | Thermoplasma acidophilum | glycolate + NADPH + H+ | - |
? | |
1.2.1.89 | glycolaldehyde + NADP+ | catalytic efficiency (kcat/Km) for glycolaldehyde is about 2% compared to the catalytic efficiency with D-glyceraldehyde | Thermoplasma acidophilum JCM 9062 | glycolate + NADPH + H+ | - |
? | |
1.2.1.89 | glycolaldehyde + NADP+ | catalytic efficiency (kcat/Km) for glycolaldehyde is 1% compared to the catalytic efficiency with D-glyceraldehyde | Picrophilus torridus DSM 9790 | glycolate + NADPH + H+ | - |
? | |
1.2.1.89 | additional information | no activity with: acetaldehyde, crotonaldehyde, benzaldehyde, succinate semialdehyde, and dihydroxyacetone | Picrophilus torridus | ? | - |
? | |
1.2.1.89 | additional information | no activity with: acetaldehyde, crotonaldehyde, benzaldehyde, succinate semialdehyde, and dihydroxyacetone | Picrophilus torridus DSM 9790 | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.1.89 | homodimer | 2 * 56000, SDS-PAGE | Thermoplasma acidophilum |
1.2.1.89 | homodimer | 2 * 56000, SDS-PAGE | Picrophilus torridus |
1.2.1.89 | homodimer | 2 * 54700, calculated from sequence | Thermoplasma acidophilum |
1.2.1.89 | homodimer | 2 * 55200, calculated from sequence | Picrophilus torridus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.89 | GADH | - |
Thermoplasma acidophilum |
1.2.1.89 | GADH | - |
Picrophilus torridus |
1.2.1.89 | Pto0332 | locus name | Picrophilus torridus |
1.2.1.89 | Ta0809 | locus name | Thermoplasma acidophilum |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 58 | - |
assay at | Thermoplasma acidophilum |
1.2.1.89 | 58 | - |
assay at | Picrophilus torridus |
1.2.1.89 | 63 | - |
- |
Thermoplasma acidophilum |
1.2.1.89 | 63 | - |
- |
Picrophilus torridus |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 60 | - |
2 h, stable | Thermoplasma acidophilum |
1.2.1.89 | 60 | - |
2 h, stable | Picrophilus torridus |
1.2.1.89 | 70 | - |
half-life: 15 min | Picrophilus torridus |
1.2.1.89 | 70 | - |
half-life: 40 min | Thermoplasma acidophilum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.89 | 10 | - |
NADP+ | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 10 | - |
D-glyceraldehyde | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 12 | - |
D-glycerate | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 20 | - |
D-glycerate | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 20 | - |
glycolaldehyde | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 25 | - |
NADP+ | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 26 | - |
D-glyceraldehyde | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 37 | - |
glycolaldehyde | pH 6.9, 58°C | Thermoplasma acidophilum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 6.6 | - |
- |
Picrophilus torridus |
1.2.1.89 | 6.9 | - |
assay at | Picrophilus torridus |
1.2.1.89 | 7.6 | - |
- |
Thermoplasma acidophilum |
1.2.1.89 | 7.9 | - |
assay at | Thermoplasma acidophilum |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.89 | 4.3 | 8.1 | pH 4.3: about 50% of maximal activity, pH 8.1: about 50% of maximal activity | Picrophilus torridus |
1.2.1.89 | 5.8 | 8.7 | pH 5.8: about 50% of maximal activity, pH 8.7: about 50% of maximal activity | Thermoplasma acidophilum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.89 | NADP+ | completely inactive with NAD+ | Thermoplasma acidophilum | |
1.2.1.89 | NADP+ | completely inactive with NAD+ | Picrophilus torridus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.2.1.89 | physiological function | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Thermoplasma acidophilum |
1.2.1.89 | physiological function | the enzyme is involved in the non-phosphorylative EntnerDoudoroff pathway | Picrophilus torridus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.89 | 1.1 | - |
D-glycerate | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 1.8 | - |
glycolaldehyde | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 2.4 | - |
D-glycerate | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 3 | - |
glycolaldehyde | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 24 | - |
NADP+ | pH 6.9, 58°C | Picrophilus torridus | |
1.2.1.89 | 70 | - |
NADP+ | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 130 | - |
D-glyceraldehyde | pH 6.9, 58°C | Thermoplasma acidophilum | |
1.2.1.89 | 167 | - |
D-glyceraldehyde | pH 6.9, 58°C | Picrophilus torridus |