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Literature summary extracted from

  • Tang, X.; Mu, P.; Wu, J.; Jiang, J.; Zhang, C.; Zheng, M.; Deng, Y.
    Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned carbonyl reductase 1 (2012), Drug Metab. Dispos., 40, 788-795.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.184 food industry mequindox, inhibitor of several Gram-positive and Gram-negative bacteria, is reduced by carbonyl reductase CBR1 Sus scrofa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.184 expression in Escherichia coli Sus scrofa
1.1.1.184 expression in Escherichia coli Gallus gallus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.184 E142M increase in reaction velocity Sus scrofa
1.1.1.184 E142V increase in reaction velocity Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.0199
-
menadione pH 7.4, 37°C Sus scrofa
1.1.1.184 0.076
-
menadione pH 7.4, 37°C Gallus gallus
1.1.1.184 0.105
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 0.116
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa
1.1.1.184 0.156
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 0.469
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.184 cytosol
-
Sus scrofa 5829
-
1.1.1.184 cytosol
-
Gallus gallus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.184 31000
-
x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Sus scrofa
1.1.1.184 31000
-
x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Gallus gallus
1.1.1.184 31590
-
x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Sus scrofa
1.1.1.184 31590
-
x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Gallus gallus F1N8Y3 putative
-
1.1.1.184 Sus scrofa Q28960
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.184 liver
-
Sus scrofa
-
1.1.1.184 liver
-
Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone + NADPH + H+ i.e. mequindox, synthetic quinoxaline derivative, inhibitory to several Gram-positive and Gram-negative bacteria Sus scrofa 1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanol + NADP+
-
?
1.1.1.184 1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone + NADPH + H+ i.e. mequindox, synthetic quinoxaline derivative, inhibitory to several Gram-positive and Gram-negative bactria Gallus gallus 1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanol + NADP+
-
?
1.1.1.184 1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone + NADPH + H+
-
Sus scrofa 1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanol + NADP+
-
?
1.1.1.184 1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone + NADPH + H+
-
Gallus gallus 1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanol + NADP+
-
?
1.1.1.184 menadione + NADPH + H+
-
Sus scrofa ? + NADP+
-
?
1.1.1.184 menadione + NADPH + H+
-
Gallus gallus ? + NADP+
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.184 ? x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Sus scrofa
1.1.1.184 ? x * 31000, SDS-PAGE, x * 31590, calculated, His-tagged protein Gallus gallus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 CBR1
-
Sus scrofa
1.1.1.184 CBR1
-
Gallus gallus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.184 0.00027
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa
1.1.1.184 0.00062
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 0.15
-
menadione pH 7.4, 37°C Sus scrofa
1.1.1.184 2.72
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 2.89
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa
1.1.1.184 4.17
-
menadione pH 7.4, 37°C Gallus gallus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.184 4
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 5.75
-
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa
1.1.1.184 7.5
-
menadione pH 7.4, 37°C Sus scrofa
1.1.1.184 25
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Sus scrofa
1.1.1.184 26
-
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone pH 7.4, 37°C Gallus gallus
1.1.1.184 54.5
-
menadione pH 7.4, 37°C Gallus gallus