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Literature summary extracted from

  • Watanabe, K.P.; Saengtienchai, A.; Tanaka, K.D.; Ikenaka, Y.; Ishizuka, M.
    Comparison of warfarin sensitivity between rat and bird species (2010), Comp. Biochem. Physiol. C, 152, 114-119.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7- and 10-hydroxylated warfarin Anas platyrhynchos
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin Bubo scandiacus
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, and 8-hydroxylated warfarin Bubo virginianus
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin Gallus gallus
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, 8- and 10-hydroxylated warfarin Rattus norvegicus
1.17.4.4 warfarin determination of warfarin metabolic rate in liver microsomes based on P450 content, overview. Conversion to 4-, 6-, 7-, and 8-hydroxylated warfarin Struthio camelus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.4 0.1658
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Gallus gallus
1.17.4.4 0.1761
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Rattus norvegicus
1.17.4.4 0.1875
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone pH 7.4, 37°C Struthio camelus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome
-
Gallus gallus
-
-
1.17.4.4 microsome
-
Rattus norvegicus
-
-
1.17.4.4 microsome
-
Anas platyrhynchos
-
-
1.17.4.4 microsome
-
Struthio camelus
-
-
1.17.4.4 microsome
-
Bubo scandiacus
-
-
1.17.4.4 microsome
-
Bubo virginianus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Gallus gallus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Rattus norvegicus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Anas platyrhynchos
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Struthio camelus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Bubo scandiacus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O Bubo virginianus
-
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Gallus gallus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Rattus norvegicus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Anas platyrhynchos
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Struthio camelus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Bubo scandiacus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O Bubo virginianus
-
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Anas platyrhynchos
-
-
-
1.17.4.4 Bubo scandiacus
-
-
-
1.17.4.4 Bubo virginianus
-
-
-
1.17.4.4 Gallus gallus
-
-
-
1.17.4.4 Rattus norvegicus
-
-
-
1.17.4.4 Struthio camelus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.4 partially by microsome preparation by ultracentrifugation Rattus norvegicus
1.17.4.4 partially by microsome preparation by ultracentrifugation Anas platyrhynchos
1.17.4.4 partially by microsome preparation by ultracentrifugation Struthio camelus
1.17.4.4 partially by microsome preparation by ultracentrifugation Bubo scandiacus
1.17.4.4 partially by microsome preparation by ultracentrifugation Bubo virginianus
1.17.4.4 partially, microsome preparation by ultracentrifugation Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
Gallus gallus
-
1.17.4.4 liver
-
Rattus norvegicus
-
1.17.4.4 liver
-
Anas platyrhynchos
-
1.17.4.4 liver
-
Struthio camelus
-
1.17.4.4 liver
-
Bubo scandiacus
-
1.17.4.4 liver
-
Bubo virginianus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Gallus gallus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Rattus norvegicus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Anas platyrhynchos 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Struthio camelus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Bubo scandiacus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol + H2O
-
Bubo virginianus 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Gallus gallus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Rattus norvegicus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Anas platyrhynchos 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Struthio camelus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Bubo scandiacus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r
1.17.4.4 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O
-
Bubo virginianus 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
r

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Gallus gallus
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Rattus norvegicus
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Anas platyrhynchos
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Struthio camelus
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Bubo scandiacus
1.17.4.4 vitamin K 2,3-epoxide reductase
-
Bubo virginianus
1.17.4.4 VKOR
-
Gallus gallus
1.17.4.4 VKOR
-
Rattus norvegicus
1.17.4.4 VKOR
-
Anas platyrhynchos
1.17.4.4 VKOR
-
Struthio camelus
1.17.4.4 VKOR
-
Bubo scandiacus
1.17.4.4 VKOR
-
Bubo virginianus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.4.4 37
-
-
Rattus norvegicus
1.17.4.4 37
-
-
Anas platyrhynchos
1.17.4.4 38
-
-
Struthio camelus
1.17.4.4 41
-
-
Bubo scandiacus
1.17.4.4 41
-
-
Bubo virginianus
1.17.4.4 42
-
-
Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.4.4 7.4
-
assay at Gallus gallus
1.17.4.4 7.4
-
assay at Rattus norvegicus
1.17.4.4 7.4
-
assay at Anas platyrhynchos
1.17.4.4 7.4
-
assay at Struthio camelus
1.17.4.4 7.4
-
assay at Bubo scandiacus
1.17.4.4 7.4
-
assay at Bubo virginianus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.4 0.00028
-
warfarin pH 7.4, 37°C Rattus norvegicus
1.17.4.4 0.00064
-
warfarin pH 7.4, 38°C Struthio camelus
1.17.4.4 0.0113
-
warfarin pH 7.4, 42°C Gallus gallus

General Information

EC Number General Information Comment Organism
1.17.4.4 evolution clear difference in VKOR activity and Ki for warfarin among bird species Gallus gallus
1.17.4.4 evolution clear difference in VKOR activity and Ki for warfarin among bird species Anas platyrhynchos
1.17.4.4 evolution clear difference in VKOR activity and Ki for warfarin among bird species Struthio camelus
1.17.4.4 evolution clear difference in VKOR activity and Ki for warfarin among bird species Bubo scandiacus
1.17.4.4 evolution clear difference in VKOR activity and Ki for warfarin among bird species Bubo virginianus