EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.5.1 | additional information | different pro-apoptotic agents responsible for complex II inhibition lead to mitochondrial matrix acidification | Homo sapiens | |
1.3.5.1 | thenoyltrifluoroacetate | inhibits a later step of the electron flow as it binds to the ubiquinone docking sites and abrogates the transfer of electrons to this molecule. It causes a time- and dose-dependent increase of apoptosis. 20% inhibition at 0.5 mM | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.5.1 | mitochondrial membrane | - |
Homo sapiens | 31966 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.5.1 | succinate + ubiquinone | Homo sapiens | - |
fumarate + ubiquinol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.5.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.5.1 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.5.1 | succinate + ubiquinone | - |
Homo sapiens | fumarate + ubiquinol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.5.1 | complex II succinate:ubiquinone oxidoreductase | - |
Homo sapiens |
1.3.5.1 | SQR | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.3.5.1 | Homo sapiens | both succinate dehydrogenase, SDH, and succinate:ubiquinone oxidoreductase, SQR, activity are markedly and equally downregulated when subunits SDHA and SDHB are targeted, and also when SDHC and SDHD are inhibited | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.3.5.1 | malfunction | the succinate:ubiquinone oxidoreductase activity of the mitochondrial respiratory complex II is specifically impaired by reactive oxygen species without affecting the second enzymatic activity of this complex as a succinate dehydrogenase. The different pro-apoptotic agents responsible for complex II inhibition lead to mitochondrial matrix acidification. Complex II contributes to apoptosis induction only when the SQR activity is inhibited while the SDH activity is still fully functioning,creating an uncoupling phenomenon at the complex II level. The association of an active SDH activity with an inhibited SQR function is not possible, rendering complex II incapable of apoptosis induction and promoting tumourigenesis | Homo sapiens |
1.3.5.1 | physiological function | succinate:ubiquinone oxidoreductase is part of the mitochondrial respiratory complex II | Homo sapiens |