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Literature summary extracted from

  • Hellenbrand, J.; Biester, E.M.; Gruber, J.; Hamberg, M.; Frentzen, M.
    Fatty acyl-CoA reductases of birds (2011), BMC Biochem., 12, 64.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.42 bovine serum albumin addition of 0.016 mM BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Tyto alba
1.2.1.42 bovine serum albumin addition of BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Gallus gallus
1.2.1.42 bovine serum albumin addition of BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Anser anser
1.2.1.42 Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Gallus gallus
1.2.1.42 Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Anser anser
1.2.1.42 Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Tyto alba

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.42 expressed in Saccharomyces cerevisiae Gallus gallus
1.2.1.42 expressed in Saccharomyces cerevisiae Anser anser
1.2.1.42 expressed in Saccharomyces cerevisiae Tyto alba

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.42 membrane
-
 Gallus gallus 16020
-
1.2.1.42 membrane
-
 Anser anser 16020
-
1.2.1.42 membrane
-
 Tyto alba 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Gallus gallus
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Anser anser
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Tyto alba
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ Gallus gallus preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ Anser anser preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ Tyto alba preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 additional information Gallus gallus the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?
1.2.1.42 additional information Anser anser the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?
1.2.1.42 additional information Tyto alba the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.42 Anser anser
-
-
-
1.2.1.42 Gallus gallus
-
-
-
1.2.1.42 Tyto alba
-
 barn owl
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.42 uropygial gland
-
 Gallus gallus
-
1.2.1.42 uropygial gland
-
 Anser anser
-
1.2.1.42 uropygial gland
-
 Tyto alba
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Gallus gallus 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Anser anser 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Tyto alba 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ preferred substrate Gallus gallus 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ preferred substrate Anser anser 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 hexadecanoyl-CoA + NADPH + H+ preferred substrate Tyto alba 1-hexadecanal + CoA + NADP+
-
 ?
1.2.1.42 additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Gallus gallus ?
-
 ?
1.2.1.42 additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Anser anser ?
-
 ?
1.2.1.42 additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Tyto alba ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.42 FAR1
-
 Gallus gallus
1.2.1.42 FAR1
-
 Anser anser
1.2.1.42 FAR1
-
 Tyto alba
1.2.1.42 fatty acyl-CoA reductase
-
 Gallus gallus
1.2.1.42 fatty acyl-CoA reductase
-
 Anser anser
1.2.1.42 fatty acyl-CoA reductase
-
 Tyto alba

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.42 37
-
 the enzymatic activity is constant for up to 15 min at 37°C Gallus gallus
1.2.1.42 37
-
 the enzymatic activity is constant for up to 15 min at 37°C Anser anser
1.2.1.42 37
-
 the enzymatic activity is constant for up to 15 min at 37°C Tyto alba

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.42 6.5
-
-
 Gallus gallus
1.2.1.42 6.5
-
-
 Anser anser
1.2.1.42 6.5
-
-
 Tyto alba

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.42 NADPH dependent on Gallus gallus
1.2.1.42 NADPH dependent on Anser anser
1.2.1.42 NADPH dependent on Tyto alba