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Literature summary extracted from

  • Chen, X.; Qi, F.; Dash, R.K.; Beard, D.A.
    Kinetics and regulation of mammalian NADH-ubiquinone oxidoreductase (Complex I) (2010), Biophys. J., 99, 1426-1436.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrial inner membrane
-
 Bos taurus 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.2 NADH + ubiquinone + 6 H+[side 1] Bos taurus
-
 NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
7.1.1.2 NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2] tri-bi enzyme mechanism combined with a simple model of the conformational changes associated with proton transport, hybrid ping-pong rapid-equilibrium random bi-bi catalytic mechanism, kinetic mechanism and general kinetic model for conformational change in a tri-bi enzyme mechanism, overview Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone + 6 H+[side 1]
-
 Bos taurus NAD+ + ubiquinol + 7 H+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Bos taurus
7.1.1.2 NADH-ubiquinone oxidoreductase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.1.1.2 25
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1.1.2 9
-
 assay at Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
7.1.1.2 6 9 activity range Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Bos taurus

General Information

EC Number General Information Comment Organism
7.1.1.2 evolution complex I has been subject to a phenomenal increase in size that predates the diversification of extant eukaryotes, followed by very few lineage-specific additions/losses of subunits Bos taurus
7.1.1.2 physiological function complex I is one of the respiratory complexes that generate the proton-motive force required for the synthesis of ATP in mitochondria. The electron transfer from NADH to ubiquinone through protein-bound prosthetic groups, which is coupled to the translocation of protons across the inner mitochondrial membrane Bos taurus