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Literature summary extracted from
- Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases (2013), Bioorg. Med. Chem. Lett., 23, 1477-1481.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.3.2.1 | disodium 3-(2-carboxylatoethyl)benzoate | - |
Escherichia coli |  |
| 3.3.2.1 | disodium 3-[(E)-2-carboxylatoethenyl]benzoate | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.1 | isochorismate + H2O | Escherichia coli | - |
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate | - |
? | |
| 3.3.2.13 | chorismate + H2O | Streptomyces hygroscopicus subsp. ascomyceticus | - |
(4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.3.2.1 | Escherichia coli | - |
- |
- |
| 3.3.2.13 | Streptomyces hygroscopicus subsp. ascomyceticus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.3.2.1 | isochorismate + H2O | - |
Escherichia coli | (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate | - |
? | |
| 3.3.2.13 | chorismate + H2O | - |
Streptomyces hygroscopicus subsp. ascomyceticus | (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.3.2.1 | EntB | - |
Escherichia coli |
| 3.3.2.13 | fkbO | - |
Streptomyces hygroscopicus subsp. ascomyceticus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.1 | 0.122 | - |
disodium 3-[(E)-2-carboxylatoethenyl]benzoate | pH and temperature not specified in the publication | Escherichia coli | |
| 3.3.2.1 | 0.282 | - |
disodium 3-(2-carboxylatoethyl)benzoate | pH and temperature not specified in the publication | Escherichia coli | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.3.2.1 | 0.209 | - |
pH and temperature not specified in the publication | Escherichia coli | disodium 3-[(E)-2-carboxylatoethenyl]benzoate | |
| 3.3.2.1 | 0.472 | - |
pH and temperature not specified in the publication | Escherichia coli | disodium 3-(2-carboxylatoethyl)benzoate | |
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