BRENDA - Enzyme Database show

Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2alpha-synthase (PGFS, AKR1C3) and 15-prostaglandin dehydrogenase

Gram, A.; Buechler, U.; Boos, A.; Hoffmann, B.; Kowalewski, M.P.; Biol. Reprod. 89, 002 (2013)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.188
Canis lupus familiaris
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
additional information
isoform AKR1C3 expression is weak or absent in luteal samples
Canis lupus familiaris
-
1.1.1.188
placenta
utero/placental expression of isoform AKR1C3 is found in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation
Canis lupus familiaris
-
1.1.1.188
uterus
uterine expression of isoforms AKR1C3 is up-regulated postimplantation and declines prepartum. Enzyme co-localizes with 15-prostaglandin dehydrogenase
Canis lupus familiaris
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.188
additional information
no activity with prostaglandin E2
724504
Canis lupus familiaris
?
-
-
-
-
1.1.1.188
prostaglandin H2 + NADPH + H+
-
724504
Canis lupus familiaris
prostaglandin F2alpha + NADP+
-
-
-
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.188
additional information
isoform AKR1C3 expression is weak or absent in luteal samples
Canis lupus familiaris
-
1.1.1.188
placenta
utero/placental expression of isoform AKR1C3 is found in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation
Canis lupus familiaris
-
1.1.1.188
uterus
uterine expression of isoforms AKR1C3 is up-regulated postimplantation and declines prepartum. Enzyme co-localizes with 15-prostaglandin dehydrogenase
Canis lupus familiaris
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.188
additional information
no activity with prostaglandin E2
724504
Canis lupus familiaris
?
-
-
-
-
1.1.1.188
prostaglandin H2 + NADPH + H+
-
724504
Canis lupus familiaris
prostaglandin F2alpha + NADP+
-
-
-
r
Expression
EC Number
Organism
Commentary
Expression
1.1.1.188
Canis lupus familiaris
uterine expression of isoforms AKR1C3 is up-regulated post implantation and declines prepartum
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.1.1.188
Canis lupus familiaris
uterine expression of isoforms AKR1C3 is up-regulated post implantation and declines prepartum
up