Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • di Salvo, M.L.; Contestabile, R.; Safo, M.K.
    Vitamin B6 salvage enzymes: mechanism, structure and regulation (2011), Biochim. Biophys. Acta, 1814, 1597-1608.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.5 R229W the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens
1.4.3.5 R95C the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens
1.4.3.5 R95H the mutation is associated with lethality in neonatal epileptic encephalopathy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.5 pyridoxal 5'-phosphate competitive inhibitor Escherichia coli
1.4.3.5 pyridoxal 5'-phosphate competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2 Escherichia coli
-
 pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2 Homo sapiens
-
 pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2 Homo sapiens
-
 pyridoxal 5'-phosphate + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2 Escherichia coli preferred substrate pyridoxal 5'-phosphate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.5 Escherichia coli
-
-
-
1.4.3.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2
-
 Escherichia coli pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxamine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + NH3 + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2
-
 Homo sapiens pyridoxal 5'-phosphate + H2O2
-
 ?
1.4.3.5 pyridoxine 5'-phosphate + H2O + O2 preferred substrate Escherichia coli pyridoxal 5'-phosphate + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.5 homodimer
-
 Escherichia coli
1.4.3.5 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.4.3.5 PNP oxidase
-
 Escherichia coli
1.4.3.5 PNP oxidase
-
 Homo sapiens
1.4.3.5 PNPOx
-
 Escherichia coli
1.4.3.5 PNPOx
-
 Homo sapiens
1.4.3.5 pyridoxine (pyridoxamine) 5'-phosphate oxidase
-
 Escherichia coli
1.4.3.5 pyridoxine (pyridoxamine) 5'-phosphate oxidase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.5 FMN dependent on Escherichia coli
1.4.3.5 FMN dependent on Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.5 0.005
-
 pyridoxal 5'-phosphate pH and temperature not specified in the publication Homo sapiens
1.4.3.5 0.008
-
 pyridoxal 5'-phosphate pH and temperature not specified in the publication Escherichia coli