EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.99.20 | microsome | 0.13 nM/min*mg | Mus musculus | - |
- |
2.4.99.20 | mitochondrion | 0.2 nM/min*mg | Mus musculus | 5739 | - |
2.4.99.20 | nucleus | 0.4 nM/min*mg | Mus musculus | 5634 | - |
2.4.99.20 | plasma membrane | 1.6 nM/min*mg | Mus musculus | 5886 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.99.20 | NADP+ + nicotinate | Rattus norvegicus | this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | nicotinate-adenine dinucleotide phosphate + nicotinamide | - |
? | |
2.4.99.20 | NADP+ + nicotinate | Mus musculus | this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | nicotinate-adenine dinucleotide phosphate + nicotinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.99.20 | Mus musculus | - |
- |
- |
2.4.99.20 | Rattus norvegicus | Q64244 | - |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate | reaction 1 b | Rattus norvegicus | |
2.4.99.20 | NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide | overall reaction. The multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | Rattus norvegicus | |
2.4.99.20 | NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide | reaction 1a | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.99.20 | brain | - |
Mus musculus | - |
2.4.99.20 | brain | - |
Rattus norvegicus | - |
2.4.99.20 | liver | - |
Rattus norvegicus | - |
2.4.99.20 | lung | - |
Rattus norvegicus | - |
2.4.99.20 | additional information | very low activity in kidney cortex and skeletal muscles | Rattus norvegicus | - |
2.4.99.20 | myocardium | - |
Rattus norvegicus | - |
2.4.99.20 | spleen | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.99.20 | 0.00000013 | - |
37°C, pH 7.2, microsome from CD38(+/+) wild-type mouse brain | Mus musculus |
2.4.99.20 | 0.0000002 | - |
37°C, pH 7.2, mitochondria from CD38(+/+) wild-type mouse brain | Mus musculus |
2.4.99.20 | 0.0000016 | - |
37°C, pH 7.2, plasma membrane from CD38(+/+) wild-type mouse brain | Mus musculus |
2.4.99.20 | 0.4 | - |
37°C, pH 7.2, nucleus from CD38(+/+) wild-type mouse brain | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate | - |
Mus musculus | nicotinate-adenine dinucleotide phosphate | - |
? | |
2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate | - |
Rattus norvegicus | nicotinate-adenine dinucleotide phosphate | - |
? | |
2.4.99.20 | NADP+ + nicotinate | - |
Mus musculus | nicotinate-adenine dinucleotide phosphate + nicotinamide | nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+ | ? | |
2.4.99.20 | NADP+ + nicotinate | - |
Rattus norvegicus | nicotinate-adenine dinucleotide phosphate + nicotinamide | nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+ | ? | |
2.4.99.20 | NADP+ + nicotinate | this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | Rattus norvegicus | nicotinate-adenine dinucleotide phosphate + nicotinamide | - |
? | |
2.4.99.20 | NADP+ + nicotinate | this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | Mus musculus | nicotinate-adenine dinucleotide phosphate + nicotinamide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.99.20 | BST1 | - |
Mus musculus |
2.4.99.20 | BST1 | - |
Rattus norvegicus |
2.4.99.20 | CD38 | - |
Mus musculus |
2.4.99.20 | CD38 | - |
Rattus norvegicus |
2.4.99.20 | diphosphopyridine nucleosidase | ambiguous | Mus musculus |
2.4.99.20 | diphosphopyridine nucleosidase | ambiguous | Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.99.20 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.99.20 | 7.2 | - |
assay at | Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.99.20 | malfunction | generation of CD38(-/-) knockout mice of determine the role of this enzyme | Mus musculus |
2.4.99.20 | physiological function | the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | Mus musculus |
2.4.99.20 | physiological function | the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes | Rattus norvegicus |