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Literature summary extracted from

  • Chini, E.N.; Chini, C.C.; Kato, I.; Takasawa, S.; Okamoto, H.
    CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues (2002), Biochem. J., 362, 125-130.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.99.20 microsome 0.13 nM/min*mg Mus musculus
-
-
2.4.99.20 mitochondrion 0.2 nM/min*mg Mus musculus 5739
-
2.4.99.20 nucleus 0.4 nM/min*mg Mus musculus 5634
-
2.4.99.20 plasma membrane 1.6 nM/min*mg Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.99.20 NADP+ + nicotinate Rattus norvegicus this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes nicotinate-adenine dinucleotide phosphate + nicotinamide
-
?
2.4.99.20 NADP+ + nicotinate Mus musculus this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes nicotinate-adenine dinucleotide phosphate + nicotinamide
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.99.20 Mus musculus
-
-
-
2.4.99.20 Rattus norvegicus Q64244
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate reaction 1 b Rattus norvegicus
2.4.99.20 NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide overall reaction. The multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes Rattus norvegicus
2.4.99.20 NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide reaction 1a Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.99.20 brain
-
Mus musculus
-
2.4.99.20 brain
-
Rattus norvegicus
-
2.4.99.20 liver
-
Rattus norvegicus
-
2.4.99.20 lung
-
Rattus norvegicus
-
2.4.99.20 additional information very low activity in kidney cortex and skeletal muscles Rattus norvegicus
-
2.4.99.20 myocardium
-
Rattus norvegicus
-
2.4.99.20 spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.99.20 0.00000013
-
37°C, pH 7.2, microsome from CD38(+/+) wild-type mouse brain Mus musculus
2.4.99.20 0.0000002
-
37°C, pH 7.2, mitochondria from CD38(+/+) wild-type mouse brain Mus musculus
2.4.99.20 0.0000016
-
37°C, pH 7.2, plasma membrane from CD38(+/+) wild-type mouse brain Mus musculus
2.4.99.20 0.4
-
37°C, pH 7.2, nucleus from CD38(+/+) wild-type mouse brain Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
Mus musculus nicotinate-adenine dinucleotide phosphate
-
?
2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate
-
Rattus norvegicus nicotinate-adenine dinucleotide phosphate
-
?
2.4.99.20 NADP+ + nicotinate
-
Mus musculus nicotinate-adenine dinucleotide phosphate + nicotinamide nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+ ?
2.4.99.20 NADP+ + nicotinate
-
Rattus norvegicus nicotinate-adenine dinucleotide phosphate + nicotinamide nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+ ?
2.4.99.20 NADP+ + nicotinate this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes Rattus norvegicus nicotinate-adenine dinucleotide phosphate + nicotinamide
-
?
2.4.99.20 NADP+ + nicotinate this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes Mus musculus nicotinate-adenine dinucleotide phosphate + nicotinamide
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.99.20 BST1
-
Mus musculus
2.4.99.20 BST1
-
Rattus norvegicus
2.4.99.20 CD38
-
Mus musculus
2.4.99.20 CD38
-
Rattus norvegicus
2.4.99.20 diphosphopyridine nucleosidase ambiguous Mus musculus
2.4.99.20 diphosphopyridine nucleosidase ambiguous Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.99.20 37
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.99.20 7.2
-
assay at Mus musculus

General Information

EC Number General Information Comment Organism
2.4.99.20 malfunction generation of CD38(-/-) knockout mice of determine the role of this enzyme Mus musculus
2.4.99.20 physiological function the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes Mus musculus
2.4.99.20 physiological function the enzyme is involved in synthesis of nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes Rattus norvegicus