Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Penning, T.; Burczynski, M.; Jez, J.; Hung, C.; Lin, H.; Ma, H.; Moore, M.; Palackal, N.; Ratnam, K.
    Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones (2000), Biochem. J., 351, 67-77.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.357 0.00144
-
 5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.0034
-
 5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.00504
-
 androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.0105
-
 3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.357 17beta-estradiol + NAD(P)H + H+ Homo sapiens
-
 estrone + NAD(P)+
-
 ?
1.1.1.357 20alpha-hydroxyprogesterone + NAD(P)H + H+ Homo sapiens
-
 progesterone + NAD(P)+
-
 ?
1.1.1.357 3alpha-androstanediol + NAD(P)+ Homo sapiens
-
 5alpha-dihydrotestosterone + NAD(P)H + H+
-
 r
1.1.1.357 5alpha-androstane-3,17-dione + NAD(P)H + H+ Homo sapiens
-
 androsterone + NAD(P)+
-
 ?
1.1.1.357 5alpha-dihydrotestosterone + NAD(P)H + H+ Homo sapiens
-
 3alpha-androstanediol + NAD(P)+
-
 r
1.1.1.357 androsterone + NAD(P)+ Homo sapiens
-
 5alpha-androstane-3,17-dione + NAD(P)H + H+
-
 ?
1.1.1.357 estrone + NAD(P)H + H+ Homo sapiens
-
 17beta-estradiol + NAD(P)+
-
 ?
1.1.1.357 progesterone + NAD(P)H + H+ Homo sapiens
-
 20alpha-hydroxyprogesterone + NAD(P)+
-
 ?
1.1.1.357 testosterone + NAD(P)H + H+ Homo sapiens
-
 DELTA4-androstene-3,17-dione + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.357 Homo sapiens P17516
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.357 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.357 17beta-estradiol + NAD(P)H + H+
-
 Homo sapiens estrone + NAD(P)+
-
 ?
1.1.1.357 20alpha-hydroxyprogesterone + NAD(P)H + H+
-
 Homo sapiens progesterone + NAD(P)+
-
 ?
1.1.1.357 3alpha-androstanediol + NAD(P)+
-
 Homo sapiens 5alpha-dihydrotestosterone + NAD(P)H + H+
-
 r
1.1.1.357 5alpha-androstane-3,17-dione + NAD(P)H + H+
-
 Homo sapiens androsterone + NAD(P)+
-
 ?
1.1.1.357 5alpha-dihydrotestosterone + NAD(P)H + H+
-
 Homo sapiens 3alpha-androstanediol + NAD(P)+
-
 r
1.1.1.357 androsterone + NAD(P)+
-
 Homo sapiens 5alpha-androstane-3,17-dione + NAD(P)H + H+
-
 ?
1.1.1.357 estrone + NAD(P)H + H+
-
 Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?
1.1.1.357 progesterone + NAD(P)H + H+
-
 Homo sapiens 20alpha-hydroxyprogesterone + NAD(P)+
-
 ?
1.1.1.357 testosterone + NAD(P)H + H+
-
 Homo sapiens DELTA4-androstene-3,17-dione + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.357 3alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.357 AKR1C4 isoform Homo sapiens
1.1.1.357 chlordecone reductase
-
 Homo sapiens
1.1.1.357 dihydrodiol dehydrogenase 4
-
 Homo sapiens
1.1.1.357 type 1 3alpha-HSD
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.357 0.023
-
 androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.03
-
 5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.033
-
 5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 0.035
-
 3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.357 NAD+
-
 Homo sapiens
1.1.1.357 NADP+
-
 Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.357 3.33
-
 3alpha-androstanediol isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 4.6
-
 androsterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 9.77
-
 5alpha-dihydrotestosterone isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens
1.1.1.357 20.72
-
 5alpha-androstane-3,17-dione isoform AKR1C4, at pH 7.4 and 25°C Homo sapiens