Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kim, J.I.; Choi, S.H.; Jung, K.J.; Lee, E.; Kim, H.Y.; Park, K.M.
    Protective role of methionine sulfoxide reductase A against ischemia/reperfusion injury in mouse kidney and its involvement in the regulation of trans-sulfuration pathway (2013), Antioxid. Redox Signal., 18, 2241-2250.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
Mus musculus
1.8.4.11 MsrA
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
Mus musculus

General Information

EC Number General Information Comment Organism
1.8.4.11 malfunction enzyme-deficient mice are more susceptible to kidney ischemia/reperfusion injury than wild type mice. Deletion of the enzyme enhances renal functional and morphological impairments, congestion, inflammatory responses, and oxidative stress under ischemia/reperfusion conditions Mus musculus
1.8.4.11 metabolism the enzyme participates in regulating methionine metabolism and the trans-sulfuration pathway under normal and ischemia/reperfusion conditions Mus musculus
1.8.4.11 physiological function the enzyme protects the kidney against ischemia/reperfusion injury. This protection is associated with reduced oxidative stress and inflammatory responses. The enzyme regulates H2S production during ischemia/reperfusion by modulating the expression and activity of the cystathionine-beta-synthase and cystathionine-gamma-lyase enzymes Mus musculus